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10.1074/jbc.M114.575571 http://scihub22266oqcxt.onion/10.1074/jbc.M114.575571 C4183780!4183780!25124033     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25124033.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (40): 27400-9 Nephropedia Template TP {{tp|p=25124033|t=2014. Degradation of Tiam1 by Casein Kinase 1 and the SCF?TrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K Signaling* |pdf=|usr=}}{{25124033}} gab.com Text Degradation of Tiam1 by Casein Kinase 1 and the SCF TrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K Signaling* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25124033 #FOAvip Background: The guanine nucleotide exchange factor Tiam1 regulates the activity of the small GTPase Rac1, a crucial regulator of cell adhesion, proliferation, and survival.Results: The SCF?TrCP ubiquitin ligase in cooperation with CK1 targets Tiam1 for proteasome-dependent degradation.Conclusion: Tiam1 degradation is required to terminate the mTOR-S6K signaling pathway.Significance: Tiam1 degradation controls the duration of mTOR-S6K signaling in response to mitogens. Twit Text FOAVip Degradation of Tiam1 by Casein Kinase 1 and the SCF TrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K Signaling* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25124033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25124033 #FOAvip English Wikipedia <ref>{{Cite pmid|25124033}}</ref> Degradation of Tiam1 by Casein Kinase 1 and the SCF?TrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K Signaling* #MMPMID25124033 Magliozzi R; Kim J; Low TY; Heck AJR; Guardavaccaro D J Biol Chem 2014[Oct]; 289 (40): 27400-9 PMID25124033show ga Background: The guanine nucleotide exchange factor Tiam1 regulates the activity of the small GTPase Rac1, a crucial regulator of cell adhesion, proliferation, and survival.Results: The SCF?TrCP ubiquitin ligase in cooperation with CK1 targets Tiam1 for proteasome-dependent degradation.Conclusion: Tiam1 degradation is required to terminate the mTOR-S6K signaling pathway.Significance: Tiam1 degradation controls the duration of mTOR-S6K signaling in response to mitogens. äDegradation of Tiam1 by Casein Kinase 1 and the SCF?TrCP Ubiquitin Lig(epmc).pdf DeepDyve Pubget Overpricing