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10.1074/jbc.M114.556563

http://scihub22266oqcxt.onion/10.1074/jbc.M114.556563
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C4183809!4183809!25104358
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suck abstract from ncbi


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pmid25104358      J+Biol+Chem 2014 ; 289 (40): 27727-43
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  • The Transcription Factor GLI1 Modulates the Inflammatory Response during Pancreatic Tissue Remodeling* #MMPMID25104358
  • Mathew E; Collins MA; Fernandez-Barrena MG; Holtz AM; Yan W; Hogan JO; Tata Z; Allen BL; Fernandez-Zapico ME; Pasca di Magliano M
  • J Biol Chem 2014[Oct]; 289 (40): 27727-43 PMID25104358show ga
  • Background:Gli1 is induced during pancreatic injury; its function remains unknown.Results: Loss of Gli1 in the stromal compartment impairs cytokine production, myeloid cell recruitment, and tissue repair.Conclusion:Gli1 regulates remodeling during pancreatic tissue recovery.Significance: This study defines a novel role for GLI1 in pancreas remodeling and expands the repertoire of target genes mediating GLI1 cellular functions.
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