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10.2215/CJN.00880114 http://scihub22266oqcxt.onion/10.2215/CJN.00880114 C4186504!4186504!25278551     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25278551.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+J+Am+Soc+Nephrol 2014 ; 9 (10): 1737-45 Nephropedia Template TP {{tp|p=25278551|t=2014. Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD: The REGARDS Study |pdf=|usr=}}{{25278551}} gab.com Text Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD: The REGARDS Study JO: Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25278551 #FOAvip Background and objectives: The term ?nondisease-specific? has been used to describe problems that cross multiple domains of health and are not necessarily the result of a single underlying disease. Although individuals with reduced eGFR and elevated albumin-to-creatinine ratio have many comorbidities, the prevalence of and outcomes associated with nondisease-specific problems have not been well studied. Design, setting, participants, & measurements: Participants included 3557 black and white United States adults ?75 years of age from the Reasons for Geographic and Racial Differences in Stroke Study. Nondisease-specific problems included cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy. Hazard ratios for mortality over a median (interquartile range) of 5.4 (4.2?6.9) years of follow-up associated with one, two, or three to six nondisease-specific problems were calculated and stratified by eGFR (?60, 45?59, and <45 ml/min per 1.73 m2) and separately, albumin-to-creatinine ratio (<30, 30?299, and ?300 mg/g). Secondary outcomes included hospitalizations and emergency department visits over 1.8 (0.7?4.0) and 2.3 (0.9?4.7) years of follow-up, respectively. Results: The prevalence of nondisease-specific problems was more common at lower eGFR and higher albumin-to-creatinine ratio levels. Within each eGFR and albumin-to-creatinine ratio strata, the risk for mortality was higher among those with a greater number of nondisease-specific problems. For example, among those with an eGFR=45?59 ml/min per 1.73 m2, the multivariable adjusted hazard ratios (95% confidence intervals) for mortality associated with one, two, or three to six nondisease-specific problems were 1.17 (0.78 to 1.76), 1.95 (1.24 to 3.07), and 2.44 (1.39 to 4.27; P trend <0.001). Risk for hospitalization and emergency department visits was higher among those with more nondisease-specific problems within eGFR and albumin-to-creatinine ratio strata. Conclusions: Among older adults, nondisease-specific problems commonly co-occur with reduced eGFR and elevated albumin-to-creatinine ratio. Identification of nondisease-specific problems may provide mortality risk information independent of measures of kidney function. Twit Text FOAVip Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD: The REGARDS Study ????Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25278551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25278551 #FOAvip English Wikipedia <ref>{{Cite pmid|25278551}}</ref> Nondisease-Specific Problems and All-Cause Mortality among Older Adults with CKD: The REGARDS Study #MMPMID25278551 Bowling CB; Booth JN; Gutiérrez OM; Kurella Tamura M; Huang L; Kilgore M; Judd S; Warnock DG; McClellan WM; Allman RM; Muntner P Clin J Am Soc Nephrol 2014[Oct]; 9 (10): 1737-45 PMID25278551show ga Background and objectives: The term ?nondisease-specific? has been used to describe problems that cross multiple domains of health and are not necessarily the result of a single underlying disease. Although individuals with reduced eGFR and elevated albumin-to-creatinine ratio have many comorbidities, the prevalence of and outcomes associated with nondisease-specific problems have not been well studied. Design, setting, participants, & measurements: Participants included 3557 black and white United States adults ?75 years of age from the Reasons for Geographic and Racial Differences in Stroke Study. Nondisease-specific problems included cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy. Hazard ratios for mortality over a median (interquartile range) of 5.4 (4.2?6.9) years of follow-up associated with one, two, or three to six nondisease-specific problems were calculated and stratified by eGFR (?60, 45?59, and <45 ml/min per 1.73 m2) and separately, albumin-to-creatinine ratio (<30, 30?299, and ?300 mg/g). Secondary outcomes included hospitalizations and emergency department visits over 1.8 (0.7?4.0) and 2.3 (0.9?4.7) years of follow-up, respectively. Results: The prevalence of nondisease-specific problems was more common at lower eGFR and higher albumin-to-creatinine ratio levels. Within each eGFR and albumin-to-creatinine ratio strata, the risk for mortality was higher among those with a greater number of nondisease-specific problems. For example, among those with an eGFR=45?59 ml/min per 1.73 m2, the multivariable adjusted hazard ratios (95% confidence intervals) for mortality associated with one, two, or three to six nondisease-specific problems were 1.17 (0.78 to 1.76), 1.95 (1.24 to 3.07), and 2.44 (1.39 to 4.27; P trend <0.001). Risk for hospitalization and emergency department visits was higher among those with more nondisease-specific problems within eGFR and albumin-to-creatinine ratio strata. Conclusions: Among older adults, nondisease-specific problems commonly co-occur with reduced eGFR and elevated albumin-to-creatinine ratio. Identification of nondisease-specific problems may provide mortality risk information independent of measures of kidney function. äNondisease-Specific Problems and All-Cause Mortality among Older Adult(epmc).pdf DeepDyve Pubget Overpricing