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10.1074/jbc.M114.588152

http://scihub22266oqcxt.onion/10.1074/jbc.M114.588152
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suck abstract from ncbi


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pmid25157107      J+Biol+Chem 2014 ; 289 (41): 28689-96
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  • Architecture of the TIM23 Inner Mitochondrial Translocon and Interactions with the Matrix Import Motor* #MMPMID25157107
  • Ting SY; Schilke BA; Hayashi M; Craig EA
  • J Biol Chem 2014[Oct]; 289 (41): 28689-96 PMID25157107show ga
  • Background: Mitochondrial import motor associates with inner membrane translocase TIM23 by undefined interactions.Results: Site-specific photo-cross-linking was detected between matrix loops of TIM23 subunits Tim23 and Tim17 with Tim44 and Pam17, respectively.Conclusion: Motor components are tethered to translocon via the scaffold Tim44, with regulatory protein Pam17 having independent interaction site.Significance: Defined motor translocon architecture provides foundation for mechanistic understanding of efficient regulated translocation.
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