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Utilization of Nephron-Sparing Surgery and Impact on Patient Survival in Pediatric Wilms Tumor ? a SEER Analysis #MMPMID24735935
Wang HHS; Abern MR; Cost NG; Chu DI; Ross SS; Wiener JS; Routh JC
J Urol 2014[Oct]; 192 (4): 1196-202 PMID24735935show ga
Purpose: Nephron-Sparing Surgery (NSS) is the standard of care for many adults with renal tumors and has been described in some children with Wilms tumor (WT). Beyond case series, however, data concerning NSS utilization and outcomes in WT are scarce. Using a large cancer data registry, we examined NSS outcomes and factors associated with NSS use in WT. Materials and Methods: We retrospectively reviewed the 1998?2010 Surveillance, Epidemiology, and End Results (SEER) database. We identified WT patients aged ? 18 years. Clinical, demographic and socioeconomic data were abstracted, and statistical analysis was performed using multivariate logistic regression (predicting use of NSS) and Cox regression (predicting Overall Survival, OS) models. Results: We identified 876 boys and 956 girls with WT (mean age 3.3 ± 2.9 years). Of these, 114 (6.2%) underwent NSS (74 unilateral, 37 bilateral WT). Median follow up was 7.1 years. Regarding procedure choice, NSS was associated with unknown lymph node status (NX vs N0, p<0.001) and smaller tumor size (p<0.001). Regarding survival, only age (HR=1.09, p=0.002), race (HR=2.48, p=0.002), stage (HR=2.99, p<0.001), and LN status (HR=2.17, p=0.001) predicted reduced OS. Survival was not significantly different for children undergoing NSS vs. RN (HR=0.79, p=0.58). Conclusions: Among children with WT included in the SEER database, NSS is infrequently performed. NSS use is associated with smaller, bilateral tumors and with omission of lymphadenectomy; however, there are no evident differences in NSS use by demographic or socioeconomic factors. Despite lymph node under-staging, overall survival after NSS remains similar to radical nephrectomy.