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10.4049/jimmunol.1402042 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402042 C4201958!4201958!25261481     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25261481.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (9): 4297-301 Nephropedia Template TP {{tp|p=25261481|t=2014. Discrete functions of mTOR signaling in iNKT cell development and NKT17 fate decision |pdf=|usr=}}{{25261481}} gab.com Text Discrete functions of mTOR signaling in iNKT cell development and NKT17 fate decision JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25261481 #FOAvip Invariant natural killer T (iNKT) cells have been recently classified into NKT1, NKT2 and NKT17 lineages with distinct transcription factor and cytokine profiles, but mechanisms underlying such fate decisions remain elusive. Here, we report crucial roles of mTOR signaling especially mTORC2 in iNKT cell development and fate determination of NKT17 cells. Loss of Rictor, an obligatory component of mTORC2, decreased thymic and peripheral iNKT cells, associated with defective survival. Strikingly, Rictor deficiency selectively abolished the NKT17 lineage, as indicated by marked reduction of ROR?t and IL-17 expression. Moreover, deletion of Pten upregulated mTORC2 activity and enhanced NKT17 generation, but concomitant loss of Rictor completely reversed the NKT17 dysregulation. In contrast, mTORC1 regulators Raptor and Rheb are dispensable for NKT17 differentiation, despite their importance in iNKT cell thymic development. Our findings establish pivotal and unique roles of mTORC2 signaling, which is reciprocally regulated by Rictor and Pten, in NKT17 lineage determination. Twit Text FOAVip Discrete functions of mTOR signaling in iNKT cell development and NKT17 fate decision ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25261481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25261481 #FOAvip English Wikipedia <ref>{{Cite pmid|25261481}}</ref> Discrete functions of mTOR signaling in iNKT cell development and NKT17 fate decision #MMPMID25261481 Wei J; Yang K; Chi H J Immunol 2014[Nov]; 193 (9): 4297-301 PMID25261481show ga Invariant natural killer T (iNKT) cells have been recently classified into NKT1, NKT2 and NKT17 lineages with distinct transcription factor and cytokine profiles, but mechanisms underlying such fate decisions remain elusive. Here, we report crucial roles of mTOR signaling especially mTORC2 in iNKT cell development and fate determination of NKT17 cells. Loss of Rictor, an obligatory component of mTORC2, decreased thymic and peripheral iNKT cells, associated with defective survival. Strikingly, Rictor deficiency selectively abolished the NKT17 lineage, as indicated by marked reduction of ROR?t and IL-17 expression. Moreover, deletion of Pten upregulated mTORC2 activity and enhanced NKT17 generation, but concomitant loss of Rictor completely reversed the NKT17 dysregulation. In contrast, mTORC1 regulators Raptor and Rheb are dispensable for NKT17 differentiation, despite their importance in iNKT cell thymic development. Our findings establish pivotal and unique roles of mTORC2 signaling, which is reciprocally regulated by Rictor and Pten, in NKT17 lineage determination. äDiscrete functions of mTOR signaling in iNKT cell development and NKT1(epmc).pdf DeepDyve Pubget Overpricing