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10.1002/0471141755.ph1430s66 http://scihub22266oqcxt.onion/10.1002/0471141755.ph1430s66 C4214366!4214366!25181010     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25181010.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Protoc+Pharmacol 2014 ; 66 (ä): 14.30.1-14.30.10 Nephropedia Template TP {{tp|p=25181010|t=2014. The DEN and CCl4-induced Mouse Model of Fibrosis and Inflammation-associated Hepatocellular Carcinoma |pdf=|usr=}}{{25181010}} gab.com Text The DEN and CCl4-induced Mouse Model of Fibrosis and Inflammation-associated Hepatocellular Carcinoma JO: Curr Protoc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25181010 #FOAvip Human hepatocellular carcinoma (HCC) mostly develops as a complication of fibrosis or cirrhosis. While most human studies of HCC provide crucial insights into the molecular signatures of HCC, seldom they address the etiology of HCC. Mouse models are essential tools for investigating pathogenesis of HCC; however, the overwhelming majority of cancer models in rodents do not feature liver fibrosis. This unit details a protocol for an experimental model of HCC in the mouse that arises in conjunction with advanced liver fibrosis. A single injection of N-nitrosodiethylamine (DEN) is followed by repeat dosing with carbon tetrachloride (CCl4). A dramatic potentiation of the liver tumor incidence can be observed following treatment with DEN and CCl4 where 100% of mice develop liver tumors at 5 months of age. This model can be utilized in studies of the molecular mechanisms of fibrogenesis and HCC development, and in cancer hazard/chemotherapy testing of novel agents. Twit Text FOAVip The DEN and CCl4-induced Mouse Model of Fibrosis and Inflammation-associated Hepatocellular Carcinoma ????Curr Protoc Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25181010 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25181010 #FOAvip English Wikipedia <ref>{{Cite pmid|25181010}}</ref> The DEN and CCl4-induced Mouse Model of Fibrosis and Inflammation-associated Hepatocellular Carcinoma #MMPMID25181010 Uehara T; Pogribny IP; Rusyn I Curr Protoc Pharmacol 2014[]; 66 (ä): 14.30.1-14.30.10 PMID25181010show ga Human hepatocellular carcinoma (HCC) mostly develops as a complication of fibrosis or cirrhosis. While most human studies of HCC provide crucial insights into the molecular signatures of HCC, seldom they address the etiology of HCC. Mouse models are essential tools for investigating pathogenesis of HCC; however, the overwhelming majority of cancer models in rodents do not feature liver fibrosis. This unit details a protocol for an experimental model of HCC in the mouse that arises in conjunction with advanced liver fibrosis. A single injection of N-nitrosodiethylamine (DEN) is followed by repeat dosing with carbon tetrachloride (CCl4). A dramatic potentiation of the liver tumor incidence can be observed following treatment with DEN and CCl4 where 100% of mice develop liver tumors at 5 months of age. This model can be utilized in studies of the molecular mechanisms of fibrogenesis and HCC development, and in cancer hazard/chemotherapy testing of novel agents. äThe DEN and CCl4-induced Mouse Model of Fibrosis and Inflammation-asso(epmc).pdf DeepDyve Pubget Overpricing