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Comprehensive Analysis of Stop Codon Usage in Bacteria and Its Correlation with Release Factor Abundance* #MMPMID25217634
Korkmaz G; Holm M; Wiens T; Sanyal S
J Biol Chem 2014[Oct]; 289 (44): 30334-42 PMID25217634show ga
Background: Stop codon frequencies in 4684 bacterial genomes are analyzed.Results: With increasing genomic GC content, TAA% decreases, and TGA% increases reciprocally, but TAG% remains almost unchanged (?20%). The TAG:TGA ratio matches well with the RF1:RF2 ratio.Conclusion: TAG is the minor stop codon, and expression of genes with TAG is correlated with the RF1 level.Significance: Our work establishes the correlation between stop codon frequency and RF1/RF2 abundance.