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10.1097/INF.0000000000000338 http://scihub22266oqcxt.onion/10.1097/INF.0000000000000338 C4217137!4217137!25361022     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25361022&cmd=llinks): Failed to open stream: HTTP request failed! 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A Hospital-Based Study of the Clinical Characteristics of Clostridium difficile Infection in Children |pdf=|usr=}}{{25361022}} gab.com Text A Hospital-Based Study of the Clinical Characteristics of Clostridium difficile Infection in Children JO: Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=25361022 #FOAvip Background: Clostridium difficile infection (CDI) is an increasingly important cause of morbidity in hospitalized children. We describe the recent epidemiology of pediatric CDI at a children?s hospital, compare community-associated (CA) and hospital-associated (HA) infections, and identify risk factors for severe disease. Methods: Children with CDI at Texas Children?s Hospital were identified from February 1, 2011 to October 31, 2011. Severe CDI was defined as the presence of a CDI-related complication or ?2 clinical features: fever, bloody stools, leukocytosis, hypoalbuminemia, or elevated creatinine. Standard epidemiologic definitions were used. Results: 109 unique patients 1-21 years of age with CDI were identified throughout the study period. The proportions of CA-CDI (41%) and HA-CDI (46%) were similar, while community-onset indeterminate CDI (13%) was less common. Children with malignancy or solid organ transplantation were more likely to have HA-CDI. Conversely, all children with inflammatory bowel disease had CA-CDI. Twenty-three patients (21%) met criteria for severe disease and 8 experienced a CDI-related complication, including 1 death attributable to CDI. On multivariate analysis, the presence of a gastrostomy tube (adjusted odds ratio 3.09; 95% CI 1.07-8.94) and having community-onset indeterminate disease (adjusted odds ratio 4.62; 95% CI 1.28-16.67) were found to be associated with severe CDI. Conclusions: A substantial proportion of pediatric CDI is community-associated and there are clinical differences between children with CA-CDI and HA-CDI. Children with CDI frequently experience severe disease, while complications are uncommon. Early identification and treatment of CDI should be pursued in children with gastrostomy tube and recent hospitalization. Twit Text FOAVip A Hospital-Based Study of the Clinical Characteristics of Clostridium difficile Infection in Children ????Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=25361022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25361022 #FOAvip English Wikipedia <ref>{{Cite pmid|25361022}}</ref> A Hospital-Based Study of the Clinical Characteristics of Clostridium difficile Infection in Children #MMPMID25361022 Crews JD; Koo HL; Jiang ZD; Starke JR; DuPont HL Pediatr Infect Dis J 2014[Sep]; 33 (9): 924-8 PMID25361022show ga Background: Clostridium difficile infection (CDI) is an increasingly important cause of morbidity in hospitalized children. We describe the recent epidemiology of pediatric CDI at a children?s hospital, compare community-associated (CA) and hospital-associated (HA) infections, and identify risk factors for severe disease. Methods: Children with CDI at Texas Children?s Hospital were identified from February 1, 2011 to October 31, 2011. Severe CDI was defined as the presence of a CDI-related complication or ?2 clinical features: fever, bloody stools, leukocytosis, hypoalbuminemia, or elevated creatinine. Standard epidemiologic definitions were used. Results: 109 unique patients 1-21 years of age with CDI were identified throughout the study period. The proportions of CA-CDI (41%) and HA-CDI (46%) were similar, while community-onset indeterminate CDI (13%) was less common. Children with malignancy or solid organ transplantation were more likely to have HA-CDI. Conversely, all children with inflammatory bowel disease had CA-CDI. Twenty-three patients (21%) met criteria for severe disease and 8 experienced a CDI-related complication, including 1 death attributable to CDI. On multivariate analysis, the presence of a gastrostomy tube (adjusted odds ratio 3.09; 95% CI 1.07-8.94) and having community-onset indeterminate disease (adjusted odds ratio 4.62; 95% CI 1.28-16.67) were found to be associated with severe CDI. Conclusions: A substantial proportion of pediatric CDI is community-associated and there are clinical differences between children with CA-CDI and HA-CDI. Children with CDI frequently experience severe disease, while complications are uncommon. Early identification and treatment of CDI should be pursued in children with gastrostomy tube and recent hospitalization. äA Hospital-Based Study of the Clinical Characteristics of Clostridium (epmc).pdf DeepDyve Pubget Overpricing