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10.1074/jbc.M114.547331

http://scihub22266oqcxt.onion/10.1074/jbc.M114.547331
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suck abstract from ncbi


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pmid25278026      J+Biol+Chem 2014 ; 289 (47): 32548-58
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  • The 3??5? DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response* #MMPMID25278026
  • Miyazaki T; Kim YS; Yoon J; Wang H; Suzuki T; Morse HC
  • J Biol Chem 2014[Nov]; 289 (47): 32548-58 PMID25278026show ga
  • Background: TREX1 is a 3??5? DNA exonuclease, and mutations in human TREX1 are associated with autoimmune/inflammatory diseases.Results: TREX1 interacts with poly(ADP-ribose) polymerase-1 (PARP1).Conclusion: TREX1 contributes to maintenance of suitable PARP1 levels and its functions in the DNA damage response.Significance: Identification of the molecular mechanism of TREX1 is necessary for understanding the development or progression of TREX1-associated diseases.
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