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10.1074/jbc.M114.605196

http://scihub22266oqcxt.onion/10.1074/jbc.M114.605196
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suck abstract from ncbi


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pmid25288788      J+Biol+Chem 2014 ; 289 (47): 32703-16
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  • High Glucose Forces a Positive Feedback Loop Connecting Akt Kinase and FoxO1 Transcription Factor to Activate mTORC1 Kinase for Mesangial Cell Hypertrophy and Matrix Protein Expression* #MMPMID25288788
  • Das F; Ghosh-Choudhury N; Dey N; Bera A; Mariappan MM; Kasinath BS; Ghosh Choudhury G
  • J Biol Chem 2014[Nov]; 289 (47): 32703-16 PMID25288788show ga
  • Background: Hyperglycemia contributes to renal hypertrophy and fibrosis.Results: Inactivation of FoxO1 is required for high glucose-induced sustained activation of Akt and mTORC1 for renal pathology.Conclusion: A positive feedback loop involving catalase exists between Akt and FoxO1.Significance: FoxO1-mediated catalase expression may alleviate renal glomerular hypertrophy and fibrosis.



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