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10.1016/j.immuni.2014.08.014

http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.08.014
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suck abstract from ncbi


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pmid25238099      Immunity 2014 ; 41 (3): 493-502
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  • Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells #MMPMID25238099
  • Calantone N; Wu F; Klase Z; Deleage C; Perkins M; Matsuda K; Thompson EA; Ortiz AM; Vinton CL; Ourmanov I; Loré K; Douek DC; Estes JD; Hirsch VM; Brenchley JM
  • Immunity 2014[Sep]; 41 (3): 493-502 PMID25238099show ga
  • The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 Asian macaques and African green monkeys with viruses that do or do not express Vpx, and examined viral targeting of cells in vivo. While lack of Vpx expression affected viral dynamics in vivo, with decreased viral loads and infection of CD4+ T cells, Vpx expression had no detectable effect on infectivity of myeloid cells. Moreover, viral DNA was only observed within myeloid cells in tissues not massively depleted of CD4+ T-cells. Myeloid cells containing viral DNA also showed evidence of T cell phagocytosis in vivo, suggesting their viral DNA may be attributed to phagocytosis of SIV-infected T cells. These data suggest that myeloid cells are not a major source of SIV in vivo, irrespective of Vpx expression.
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