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10.1074/jbc.M114.585356

http://scihub22266oqcxt.onion/10.1074/jbc.M114.585356
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C4246092!4246092!25315770
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suck abstract from ncbi


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pmid25315770      J+Biol+Chem 2014 ; 289 (48): 33355-63
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  • Novel Peptide for Attenuation of Hyperoxia-induced Disruption of Lung Endothelial Barrier and Pulmonary Edema via Modulating Peroxynitrite Formation* #MMPMID25315770
  • Kondrikov D; Gross C; Black SM; Su Y
  • J Biol Chem 2014[Nov]; 289 (48): 33355-63 PMID25315770show ga
  • Background: Hyperoxia increases NO and peroxynitrite in lung endothelium via increased interaction of eNOS with ?-actin.Results: P326TAT with sequence corresponding to actin binding region of eNOS residues 326?333 inhibited hyperoxia-induced disruption of endothelial barrier and apoptosis in cell culture and animal model.Conclusion: P326TAT ameliorates barrier dysfunction of hyperoxic lung endothelium and pulmonary edema.Significance: P326TAT can be a novel therapeutic agent to treat acute hyperoxic lung injury.
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