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10.1097/BOR.0000000000000113

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C4299717!4299717!25203118
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suck abstract from ncbi


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pmid25203118      Curr+Opin+Rheumatol 2014 ; 26 (6): 646-52
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  • Scleroderma: the role of serum autoantibodies in defining specific clinical phenotypes and organ system involvement #MMPMID25203118
  • Domsic RT
  • Curr Opin Rheumatol 2014[Nov]; 26 (6): 646-52 PMID25203118show ga
  • Purpose of review: To discuss recent advances in serologic testing for SSc-associated antibodies with respect to the diagnosis and prognosis of the disease. Recent findings: The importance of SSc antibodies for diagnosis has become increasingly recognized, as evidence by incorporation into the 2013 ACR/EULAR clinical classification criteria for SSc. Two new SSc-associated antibodies and their clinical associations have been described. Multiple cohort studies have reported variable antibody frequency distribution based on geography, but the clinical associations remain much the same. New associations include anti-RNA polymerase III antibodies with gastric antral vascular ectasia, and a temporal association between SSc onset and RNA polymerase III antibodies. Summary: The role and associations of SSc-associated antibodies for diagnosis and internal organ involvement is becoming increasingly accepted.



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