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10.4049/jimmunol.1402051 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402051 C4308418!4308418!25320273     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25320273&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25320273.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2014 ; 193 (10): 4779-82 Nephropedia Template TP {{tp|p=25320273|t=2014. STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation |pdf=|usr=}}{{25320273}} gab.com Text STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip STING is a cytoplasmic innate immune sensor for cyclic dinucleotides, which also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. Here, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit elevated intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-?B and STAT3 signaling pathways, which leads to increased levels of the pro-inflammatory cytokines IL-6 and KC. Our results, therefore, identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. Twit Text FOAVip STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25320273 #FOAvip English Wikipedia <ref>{{Cite pmid|25320273}}</ref> STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation #MMPMID25320273 Zhu Q; Man SM; Gurung P; Liu Z; Vogel P; Lamkanfi M; Kanneganti TD J Immunol 2014[Nov]; 193 (10): 4779-82 PMID25320273show ga STING is a cytoplasmic innate immune sensor for cyclic dinucleotides, which also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. Here, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit elevated intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-?B and STAT3 signaling pathways, which leads to increased levels of the pro-inflammatory cytokines IL-6 and KC. Our results, therefore, identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. äSTING mediates protection against colorectal tumorigenesis by governin(epmc).pdf DeepDyve Pubget Overpricing