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10.1073/pnas.1424217112 http://scihub22266oqcxt.onion/10.1073/pnas.1424217112 C4311832!4311832!25568082     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25568082&cmd=llinks): Failed to open stream: HTTP request failed! 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In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA |pdf=|usr=}}{{25568082}} gab.com Text In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25568082 #FOAvip MicroRNAs limit gene expression by recruiting a large protein complex known as the RNA-induced silencing complex (RISC) to target mRNAs. While attempting to understand physiological regulation of RISC assembly, we found that most healthy adult tissues retain a reserve of microRNAs not stably associated with target mRNA. Recruitment of microRNAs to large mRNA-containing complexes was accompanied by an increase in their ability to repress targets and was regulated in part by phosphoinositide-3 kinase?RAC-alpha serine/threonine-protein kinase?mechanistic target of rapamycin pathway-dependent enhancement of the glycine-tryptophan protein of 182 kDa protein expression. Data presented here suggest that in vivo, many expressed microRNAs exist in an inactive reserve, allowing resting cells to use microRNAs to dynamically regulate the translation of target mRNAs in their environment. Twit Text FOAVip In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25568082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25568082 #FOAvip English Wikipedia <ref>{{Cite pmid|25568082}}</ref> In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA #MMPMID25568082 La Rocca G; Olejniczak SH; González AJ; Briskin D; Vidigal JA; Spraggon L; DeMatteo RG; Radler MR; Lindsten T; Ventura A; Tuschl T; Leslie CS; Thompson CB Proc Natl Acad Sci U S A 2015[Jan]; 112 (3): 767-72 PMID25568082show ga MicroRNAs limit gene expression by recruiting a large protein complex known as the RNA-induced silencing complex (RISC) to target mRNAs. While attempting to understand physiological regulation of RISC assembly, we found that most healthy adult tissues retain a reserve of microRNAs not stably associated with target mRNA. Recruitment of microRNAs to large mRNA-containing complexes was accompanied by an increase in their ability to repress targets and was regulated in part by phosphoinositide-3 kinase?RAC-alpha serine/threonine-protein kinase?mechanistic target of rapamycin pathway-dependent enhancement of the glycine-tryptophan protein of 182 kDa protein expression. Data presented here suggest that in vivo, many expressed microRNAs exist in an inactive reserve, allowing resting cells to use microRNAs to dynamically regulate the translation of target mRNAs in their environment. äIn vivo, Argonaute-bound microRNAs exist predominantly in a reservoir (epmc).pdf DeepDyve Pubget Overpricing