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10.1128/AAC.04252-14 http://scihub22266oqcxt.onion/10.1128/AAC.04252-14 C4325791!4325791!25534724     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25534724&cmd=llinks): Failed to open stream: HTTP request failed! 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Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections |pdf=|usr=}}{{25534724}} gab.com Text Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25534724 #FOAvip Clostridium difficile infection causes diarrheal disease with potentially fatal complications. Although treatments are available, including vancomycin, metronidazole, and fidaxomicin, the recurrence of disease after therapy remains a problem. LFF571 is a novel thiopeptide antibacterial that shows in vitro potency against C. difficile that is comparable to or greater than that of other clinically used antibiotics. Here, we compare the pharmacokinetics (PK) of LFF571 and vancomycin in patients with C. difficile infection as part of an early efficacy study. This multicenter, randomized, evaluator-blind, and active-controlled study evaluated the safety, efficacy, and pharmacokinetics of LFF571 in adults with primary episodes or first relapses of moderate C. difficile infections. Patients were randomized to receive 200 mg of LFF571 or 125 mg of vancomycin four times daily for 10 days. The PK parameters were calculated from drug concentrations measured in serum and fecal samples. The systemic exposure following oral administration of 200 mg of LFF571 four times per day for 10 days in patients with C. difficile infection was limited. The highest LFF571 serum concentration observed was 41.7 ng/ml, whereas the levels in feces at the end of treatment were between 107 and 12,900 ?g/g. In comparison, the peak vancomycin level observed in serum was considerably higher, at 2.73 ?g/ml; the levels of vancomycin in feces were not measured. Similar to healthy volunteers, patients with C. difficile infections exhibited high fecal concentrations and low serum levels of LFF571. These results are consistent with the retention of LFF571 in the lumen of the gastrointestinal tract. (This study has been registered at ClinicalTrials.gov under registration no. NCT01232595.) Twit Text FOAVip Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=25534724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25534724 #FOAvip English Wikipedia <ref>{{Cite pmid|25534724}}</ref> Pharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile Infections #MMPMID25534724 Bhansali SG; Mullane K; Ting LSL; Leeds JA; Dabovic K; Praestgaard J; Pertel P Antimicrob Agents Chemother 2015[Mar]; 59 (3): 1441-5 PMID25534724show ga Clostridium difficile infection causes diarrheal disease with potentially fatal complications. Although treatments are available, including vancomycin, metronidazole, and fidaxomicin, the recurrence of disease after therapy remains a problem. LFF571 is a novel thiopeptide antibacterial that shows in vitro potency against C. difficile that is comparable to or greater than that of other clinically used antibiotics. Here, we compare the pharmacokinetics (PK) of LFF571 and vancomycin in patients with C. difficile infection as part of an early efficacy study. This multicenter, randomized, evaluator-blind, and active-controlled study evaluated the safety, efficacy, and pharmacokinetics of LFF571 in adults with primary episodes or first relapses of moderate C. difficile infections. Patients were randomized to receive 200 mg of LFF571 or 125 mg of vancomycin four times daily for 10 days. The PK parameters were calculated from drug concentrations measured in serum and fecal samples. The systemic exposure following oral administration of 200 mg of LFF571 four times per day for 10 days in patients with C. difficile infection was limited. The highest LFF571 serum concentration observed was 41.7 ng/ml, whereas the levels in feces at the end of treatment were between 107 and 12,900 ?g/g. In comparison, the peak vancomycin level observed in serum was considerably higher, at 2.73 ?g/ml; the levels of vancomycin in feces were not measured. Similar to healthy volunteers, patients with C. difficile infections exhibited high fecal concentrations and low serum levels of LFF571. These results are consistent with the retention of LFF571 in the lumen of the gastrointestinal tract. (This study has been registered at ClinicalTrials.gov under registration no. NCT01232595.) äPharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Cl(epmc).pdf DeepDyve Pubget Overpricing