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10.1097/MOL.0000000000000107 http://scihub22266oqcxt.onion/10.1097/MOL.0000000000000107 C4339278!4339278!25188917     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25188917&cmd=llinks): Failed to open stream: HTTP request failed! 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Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis |pdf=|usr=}}{{25188917}} gab.com Text Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis JO: Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=25188917 #FOAvip Purpose of review: Great effort has been devoted to elucidate the molecular mechanisms by which inflammasome in macrophages contributes to atherosclerosis. Inflammasome in vascular endothelial cells (ECs) and its causal relationship with endothelial dysfunction in atherosclerosis are less understood. Here we review recent studies of inflammasome and its activation in ECs, and highlight such endothelial inflammatory response in atherosclerosis. Recent findings: Inflammasomes are critical effectors in innate immunity, and their activation in macrophages and the arterial wall contributes to atherogenesis. Sterol regulatory element-binding protein 2 (SREBP2), a master regulator in cholesterol biosynthesis, can be activated in a non-canonical manner, which leads to activation of the inflammasome NOD-like receptor family pyrin domain-containing protein (NLRP) in macrophages and ECs. Results from in vitro and in vivo models suggest that SREBP2 is a key molecule in aggravating pro-inflammatory responses in ECs, and promoting atherosclerosis. Summary: The SREBP-induced NLRP inflammasome and its instigation of innate immunity is an important contributor to atherosclerosis. Elucidating the underlying mechanisms will expand our understanding of endothelial dysfunction and its dynamic interaction with vascular inflammation. Furthermore, targeting SREBP-inflammasome pathways can be a therapeutic strategy for attenuating atherosclerosis. Twit Text FOAVip Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis ????Curr Opin Lipidol http://www.kidney.de/pget.php?&tw=1&pmid=25188917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25188917 #FOAvip English Wikipedia <ref>{{Cite pmid|25188917}}</ref> Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis #MMPMID25188917 Chen Z; Martin M; Li Z; Shyy JYJ Curr Opin Lipidol 2014[Oct]; 25 (5): 339-49 PMID25188917show ga Purpose of review: Great effort has been devoted to elucidate the molecular mechanisms by which inflammasome in macrophages contributes to atherosclerosis. Inflammasome in vascular endothelial cells (ECs) and its causal relationship with endothelial dysfunction in atherosclerosis are less understood. Here we review recent studies of inflammasome and its activation in ECs, and highlight such endothelial inflammatory response in atherosclerosis. Recent findings: Inflammasomes are critical effectors in innate immunity, and their activation in macrophages and the arterial wall contributes to atherogenesis. Sterol regulatory element-binding protein 2 (SREBP2), a master regulator in cholesterol biosynthesis, can be activated in a non-canonical manner, which leads to activation of the inflammasome NOD-like receptor family pyrin domain-containing protein (NLRP) in macrophages and ECs. Results from in vitro and in vivo models suggest that SREBP2 is a key molecule in aggravating pro-inflammatory responses in ECs, and promoting atherosclerosis. Summary: The SREBP-induced NLRP inflammasome and its instigation of innate immunity is an important contributor to atherosclerosis. Elucidating the underlying mechanisms will expand our understanding of endothelial dysfunction and its dynamic interaction with vascular inflammation. Furthermore, targeting SREBP-inflammasome pathways can be a therapeutic strategy for attenuating atherosclerosis. äEndothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome (epmc).pdf DeepDyve Pubget Overpricing