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Sulfide Oxidation by a Noncanonical Pathway in Red Blood Cells Generates Thiosulfate and Polysulfides* #MMPMID25688092
Vitvitsky V; Yadav PK; Kurthen A; Banerjee R
J Biol Chem 2015[Mar]; 290 (13): 8310-20 PMID25688092show ga
Background: RBCs produce H2S but, lacking mitochondria, are devoid of the canonical sulfide oxidation pathway.Results: RBCs utilize methemoglobin to catalyze H2S oxidation producing thiosulfate and polysulfide.Conclusion: In the presence of NADPH and a reductase, ferric sulfide hemoglobin is converted to oxyhemoglobin, completing the sulfide oxidation cycle.Significance: We describe a novel mechanism for H2S oxidation that may be pertinent to other hemeproteins.