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10.1038/bjc.2015.67 http://scihub22266oqcxt.onion/10.1038/bjc.2015.67 C4385959!4385959!25719834     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25719834&cmd=llinks): Failed to open stream: HTTP request failed! 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The neutrophil?lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials |pdf=|usr=}}{{25719834}} gab.com Text The neutrophil lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25719834 #FOAvip Background:: Inflammation is critical to the pathogenesis and progression of cancer, with a high neutrophil?lymphocyte ratio (NLR) associated with poor prognosis. The utility of studying NLR in early clinical trials is unknown. Methods:: This retrospective study evaluated 1300 patients treated in phase 1 clinical trials between July 2004 and February 2014 at the Royal Marsden Hospital (RMH), UK. Data were collected on patient characteristics and baseline laboratory parameters. Results:: The test cohort recruited 300 patients; 53% were female, 35% ECOG 0 and 64% ECOG 1. RMH score was 0?1 in 66% and 2?3 in 34%. The median NLR was 3.08 (IQR 2.06?4.49). Median OS for the NLR quartiles was 10.5 months for quartile-1, 10.3 months for quartile-2, 7.9 months for quartile-3 and 6.5 months for quartile-4 (P<0.0001). Univariate analysis identified RMH score (HR=0.55, P<0.0001), ECOG (HR=0.62, P=0.002) and neutrophils (HR=0.65, P=0.003) to be associated with OS. In multivariate analysis, adjusting for RMH score, ECOG, neutrophils and tumour type, NLR remained significantly associated with OS (P=0.002), with no association with therapeutic steroid use. These results were validated in a further 1000 cancer patients. In the validation cohort, NLR was able to discriminate for OS (P=0.004), as was the RMH score. This was further improved on in the RMH score+NLR50 and RMH score+Log10NLR models, with an optimal NLR cutoff of 3.0. Conclusions:: NLR is a validated independent prognostic factor for OS in patients treated in phase 1 trials. Combining the NLR with the RMH score improves the discriminating ability for OS. Twit Text FOAVip The neutrophil lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25719834 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25719834 #FOAvip English Wikipedia <ref>{{Cite pmid|25719834}}</ref> The neutrophil?lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials #MMPMID25719834 Kumar R; Geuna E; Michalarea V; Guardascione M; Naumann U; Lorente D; Kaye SB; de Bono JS Br J Cancer 2015[Mar]; 112 (7): 1157-65 PMID25719834show ga Background:: Inflammation is critical to the pathogenesis and progression of cancer, with a high neutrophil?lymphocyte ratio (NLR) associated with poor prognosis. The utility of studying NLR in early clinical trials is unknown. Methods:: This retrospective study evaluated 1300 patients treated in phase 1 clinical trials between July 2004 and February 2014 at the Royal Marsden Hospital (RMH), UK. Data were collected on patient characteristics and baseline laboratory parameters. Results:: The test cohort recruited 300 patients; 53% were female, 35% ECOG 0 and 64% ECOG 1. RMH score was 0?1 in 66% and 2?3 in 34%. The median NLR was 3.08 (IQR 2.06?4.49). Median OS for the NLR quartiles was 10.5 months for quartile-1, 10.3 months for quartile-2, 7.9 months for quartile-3 and 6.5 months for quartile-4 (P<0.0001). Univariate analysis identified RMH score (HR=0.55, P<0.0001), ECOG (HR=0.62, P=0.002) and neutrophils (HR=0.65, P=0.003) to be associated with OS. In multivariate analysis, adjusting for RMH score, ECOG, neutrophils and tumour type, NLR remained significantly associated with OS (P=0.002), with no association with therapeutic steroid use. These results were validated in a further 1000 cancer patients. In the validation cohort, NLR was able to discriminate for OS (P=0.004), as was the RMH score. This was further improved on in the RMH score+NLR50 and RMH score+Log10NLR models, with an optimal NLR cutoff of 3.0. Conclusions:: NLR is a validated independent prognostic factor for OS in patients treated in phase 1 trials. Combining the NLR with the RMH score improves the discriminating ability for OS. äThe neutrophil?lymphocyte ratio and its utilisation for the management(epmc).pdf DeepDyve Pubget Overpricing