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10.1186/s12967-015-0467-3

http://scihub22266oqcxt.onion/10.1186/s12967-015-0467-3
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suck abstract from ncbi


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pmid25884481      J+Transl+Med 2015 ; 13 (ä): ä
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  • The non-coding RNAs of the H19-IGF2 imprinted loci: A focus on biological roles and therapeutic potential in Lung Cancer #MMPMID25884481
  • Matouk IJ; Halle D; Gilon M; Hochberg A
  • J Transl Med 2015[]; 13 (ä): ä PMID25884481show ga
  • Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described.
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