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10.1074/jbc.M115.636936

http://scihub22266oqcxt.onion/10.1074/jbc.M115.636936
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suck abstract from ncbi


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pmid25694425      J+Biol+Chem 2015 ; 290 (16): 10418-29
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  • Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES* #MMPMID25694425
  • Singh D; Gawel D; Itsko M; Hochkoeppler A; Krahn JM; London RE; Schaaper RM
  • J Biol Chem 2015[Apr]; 290 (16): 10418-29 PMID25694425show ga
  • Background: The Escherichia coli Dgt enzyme hydrolyzes the important DNA building block dGTP, but the cellular role of this activity is still unclear.Results: The enzyme is shown to be a hexameric structure containing regulatory DNA molecules.Conclusion: DNA mediates the regulation of dGTPase activity in the cell.Significance: This is the first demonstration of regulation of dNTPase by DNA.
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