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10.1016/j.immuni.2015.03.006 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.03.006 C4412374!4412374!25888258     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25888258&cmd=llinks): Failed to open stream: HTTP request failed! 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NLRP12 negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells |pdf=|usr=}}{{25888258}} gab.com Text NLRP12 negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25888258 #FOAvip Missense mutations in the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are associated with periodic fever syndromes and atopic dermatitis in humans. Here, we have demonstrated a crucial role for NLRP12 in negatively regulating pathogenic T cell responses. Nlrp12?/? mice responded to antigen immunization with hyperinflammatory T cell responses. Furthermore, transfer of CD4+CD45RBhiNlrp12?/? T cells into immunodeficient mice led to more severe colitis and atopic dermatitis. NLRP12-deficiency did not, however, cause exacerbated ascending paralysis during experimental autoimmune encephalomyelitis (EAE), instead Nlrp12?/? mice developed atypical neuroinflammatory symptoms that were characterized by ataxia and loss of balance. Enhanced T cell-mediated interleukin-4 (IL-4) production promotes the development of atypical EAE disease in Nlrp12?/? mice. These results define an unexpected role for NLRP12 as an intrinsic negative regulator of T cell-mediated immunity, and identify altered NF-?B regulation and IL-4 production as key mediators of NLRP12-associated disease. Twit Text FOAVip NLRP12 negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25888258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25888258 #FOAvip English Wikipedia <ref>{{Cite pmid|25888258}}</ref> NLRP12 negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells #MMPMID25888258 Lukens JR; Gurung P; Shaw PJ; Barr MJ; Zaki MH; Brown S; Vogel P; Chi H; Kanneganti TD Immunity 2015[Apr]; 42 (4): 654-64 PMID25888258show ga Missense mutations in the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are associated with periodic fever syndromes and atopic dermatitis in humans. Here, we have demonstrated a crucial role for NLRP12 in negatively regulating pathogenic T cell responses. Nlrp12?/? mice responded to antigen immunization with hyperinflammatory T cell responses. Furthermore, transfer of CD4+CD45RBhiNlrp12?/? T cells into immunodeficient mice led to more severe colitis and atopic dermatitis. NLRP12-deficiency did not, however, cause exacerbated ascending paralysis during experimental autoimmune encephalomyelitis (EAE), instead Nlrp12?/? mice developed atypical neuroinflammatory symptoms that were characterized by ataxia and loss of balance. Enhanced T cell-mediated interleukin-4 (IL-4) production promotes the development of atypical EAE disease in Nlrp12?/? mice. These results define an unexpected role for NLRP12 as an intrinsic negative regulator of T cell-mediated immunity, and identify altered NF-?B regulation and IL-4 production as key mediators of NLRP12-associated disease. �NLRP12 negatively regulates autoinflammatory disease by modulating int(epmc).pdf DeepDyve Pubget Overpricing