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10.1073/pnas.1505244112 http://scihub22266oqcxt.onion/10.1073/pnas.1505244112 C4413296!4413296!25852146     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25852146.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (16): 5017-22 Nephropedia Template TP {{tp|p=25852146|t=2015. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis |pdf=|usr=}}{{25852146}} gab.com Text A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25852146 #FOAvip Necroptosis is a form of programmed necrotic cell death controlled by receptor-interacting protein kinase 3, RIP3. RIP3 exists in live cells as a latent form in the cytosol and is activated by death-inducing cytokines such as tumor necrosis factor. We report here that RIP3 activation requires Heat Shock Protein 90, HSP90, and its cochaperone protein CDC37. HSP90 inhibitors, currently under investigation in clinical trials for a variety of cancer indications, are capable of inhibiting necroptosis at concentrations below the clinically achieved concentration in patients? sera. Since the components of the necroptosis pathway are being pursued as potential drug targets for many degenerative diseases, the finding described here revealed that there are already clinical stage molecules available to inhibit necroptosis. Twit Text FOAVip A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25852146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25852146 #FOAvip English Wikipedia <ref>{{Cite pmid|25852146}}</ref> A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis #MMPMID25852146 Li D; Xu T; Cao Y; Wang H; Li L; Chen S; Wang X; Shen Z Proc Natl Acad Sci U S A 2015[Apr]; 112 (16): 5017-22 PMID25852146show ga Necroptosis is a form of programmed necrotic cell death controlled by receptor-interacting protein kinase 3, RIP3. RIP3 exists in live cells as a latent form in the cytosol and is activated by death-inducing cytokines such as tumor necrosis factor. We report here that RIP3 activation requires Heat Shock Protein 90, HSP90, and its cochaperone protein CDC37. HSP90 inhibitors, currently under investigation in clinical trials for a variety of cancer indications, are capable of inhibiting necroptosis at concentrations below the clinically achieved concentration in patients? sera. Since the components of the necroptosis pathway are being pursued as potential drug targets for many degenerative diseases, the finding described here revealed that there are already clinical stage molecules available to inhibit necroptosis. �A cytosolic heat shock protein 90 and cochaperone CDC37 complex is req(epmc).pdf DeepDyve Pubget Overpricing