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10.1001/jamadermatol.2013.7954 http://scihub22266oqcxt.onion/10.1001/jamadermatol.2013.7954 C4414492!4414492!24401911     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24401911&cmd=llinks): Failed to open stream: HTTP request failed! 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Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis |pdf=|usr=}}{{24401911}} gab.com Text Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis JO: JAMA Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip Importance: Atopic dermatitis (AD) is a common chronic illness of childhood. Objective: The goal of this study was to evaluate the association between Thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. Design: Prospective cohort study Setting: General community Participants: Children enrolled in the Pediatric Eczema Elective Registry. Exposures: Evaluation of TSLP variation.Main outcomes and measures: Self-reported outcome of whether or not a child?s skin was AD symptom-free for 6-months at 6 month intervals. Results: We evaluated 14 variants of TSLP. TSLP variant rs1898671 was significantly associated with the outcome in white subjects (p = 0.014). As measured by overlapping confidence intervals, similar ORs were noted among whites (1.72 (1.11, 2.65)) and African-American (1.34(0.51, 3.51)). Further within the subcohort of individuals with a FLG loss of function mutation, those with TSLP variation were more likely to have less persistent disease ((4.92 (2.04, 11.86)). Conclusions and relevance: With respect to the clinical persistence of AD, TSLP variation is associated with less persistent disease. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in those with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials. Twit Text FOAVip Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis ????JAMA Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip English Wikipedia <ref>{{Cite pmid|24401911}}</ref> Thymic stromal lymphopoietin variation, filaggrin loss-of-function, and the persistence of atopic dermatitis #MMPMID24401911 Margolis DJ; Kim B; Apter AJ; Gupta J; Hoffstad O; Papadopoulos M; Mitra N JAMA Dermatol 2014[Mar]; 150 (3): 254-9 PMID24401911show ga Importance: Atopic dermatitis (AD) is a common chronic illness of childhood. Objective: The goal of this study was to evaluate the association between Thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. Design: Prospective cohort study Setting: General community Participants: Children enrolled in the Pediatric Eczema Elective Registry. Exposures: Evaluation of TSLP variation.Main outcomes and measures: Self-reported outcome of whether or not a child?s skin was AD symptom-free for 6-months at 6 month intervals. Results: We evaluated 14 variants of TSLP. TSLP variant rs1898671 was significantly associated with the outcome in white subjects (p = 0.014). As measured by overlapping confidence intervals, similar ORs were noted among whites (1.72 (1.11, 2.65)) and African-American (1.34(0.51, 3.51)). Further within the subcohort of individuals with a FLG loss of function mutation, those with TSLP variation were more likely to have less persistent disease ((4.92 (2.04, 11.86)). Conclusions and relevance: With respect to the clinical persistence of AD, TSLP variation is associated with less persistent disease. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in those with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials. äThymic stromal lymphopoietin variation, filaggrin loss-of-function, an(epmc).pdf DeepDyve Pubget Overpricing