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10.1074/jbc.M114.631622

http://scihub22266oqcxt.onion/10.1074/jbc.M114.631622
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suck abstract from ncbi


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pmid25645918      J+Biol+Chem 2015 ; 290 (14): 8789-802
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  • Human Neutrophils Secrete Bioactive Paucimannosidic Proteins from Azurophilic Granules into Pathogen-Infected Sputum* #MMPMID25645918
  • Thaysen-Andersen M; Venkatakrishnan V; Loke I; Laurini C; Diestel S; Parker BL; Packer NH
  • J Biol Chem 2015[Apr]; 290 (14): 8789-802 PMID25645918show ga
  • Background: Protein paucimannosylation is considered an important invertebrate- and plant-specific glycoepitope.Results: Azurophilic granule-specific human neutrophil proteins from pathogen-infected sputum displayed significant core-fucosylated paucimannosylation generated by maturation- and granule-specific ?-hexosaminidase A and were preferentially secreted from non-lysosomal origins into sputum upon P. aeruginosa stimulation.Conclusion: Human neutrophils produce, store, and selectively secrete bioactive paucimannosidic proteins.Significance: This work will aid in understanding the function(s) of human paucimannosylation in glycoimmunology.
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