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Adrenal androgens and androgen precursors: definition, synthesis, regulation and physiologic actions #MMPMID25428847
Turcu A; Smith JM; Auchus R; Rainey WE
Compr Physiol 2014[Oct]; 4 (4): 1369-81 PMID25428847show ga
The human adrenal produces more 19 carbon (C19) steroids, by mass, than either glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C19 steroid biosynthesis continue to represent one of the most intriguing mysteries of endocrine physiology. This review will discuss the C19 steroids produced in the human adrenal and the features within the adrenal that allow production of these steroids. Finally, we consider the effects of these steroids in normal physiology and disorders of adrenal C19 steroid excess.