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10.1111/gbb.12217 http://scihub22266oqcxt.onion/10.1111/gbb.12217 C4444045!4444045!25868909     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25868909&cmd=llinks): Failed to open stream: HTTP request failed! 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The burrowing behavior of the nematode Caenorhabditis elegans: A new assay for the study of neuromuscular disorders |pdf=|usr=}}{{25868909}} gab.com Text The burrowing behavior of the nematode Caenorhabditis elegans: A new assay for the study of neuromuscular disorders JO: Genes Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=25868909 #FOAvip The nematode Caenorhabditis elegans has been a powerful model system for the study of key muscle genes relevant to human neuromuscular function and disorders. The behavioral robustness of C. elegans, however, has hindered its use in the study of certain neuromuscular disorders because many worm models of human disease show only subtle phenotypes while crawling. By contrast, in their natural habitat, C. elegans likely spends much of the time burrowing through the soil matrix. We developed a burrowing assay to challenge motor output by placing worms in agar-filled pipettes of increasing densities. We find that burrowing involves distinct kinematics and turning strategies from crawling that vary with the properties of the substrate. We show that mutants mimicking Duchenne muscular dystrophy by lacking a functional ortholog of the dystrophin protein, DYS-1, crawl normally but are severely impaired in burrowing. Muscular degeneration in the dys-1 mutant is hastened and exacerbated by burrowing, while wild-type shows no such damage. To test whether neuromuscular integrity might be compensated genetically in the dys-1 mutant, we performed a genetic screen and isolated several suppressor mutants with proficient burrowing in a dys-1 mutant background. Further study of burrowing in C. elegans will enhance the study of diseases affecting neuromuscular integrity, and will provide insights into the natural behavior of this and other nematodes. Twit Text FOAVip The burrowing behavior of the nematode Caenorhabditis elegans: A new assay for the study of neuromuscular disorders ????Genes Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=25868909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25868909 #FOAvip English Wikipedia <ref>{{Cite pmid|25868909}}</ref> The burrowing behavior of the nematode Caenorhabditis elegans: A new assay for the study of neuromuscular disorders #MMPMID25868909 Beron C; Vidal-Gadea AG; Cohn J; Parikh A; Huong G; Pierce-Shimomura JT Genes Brain Behav 2015[Apr]; 14 (4): 357-68 PMID25868909show ga The nematode Caenorhabditis elegans has been a powerful model system for the study of key muscle genes relevant to human neuromuscular function and disorders. The behavioral robustness of C. elegans, however, has hindered its use in the study of certain neuromuscular disorders because many worm models of human disease show only subtle phenotypes while crawling. By contrast, in their natural habitat, C. elegans likely spends much of the time burrowing through the soil matrix. We developed a burrowing assay to challenge motor output by placing worms in agar-filled pipettes of increasing densities. We find that burrowing involves distinct kinematics and turning strategies from crawling that vary with the properties of the substrate. We show that mutants mimicking Duchenne muscular dystrophy by lacking a functional ortholog of the dystrophin protein, DYS-1, crawl normally but are severely impaired in burrowing. Muscular degeneration in the dys-1 mutant is hastened and exacerbated by burrowing, while wild-type shows no such damage. To test whether neuromuscular integrity might be compensated genetically in the dys-1 mutant, we performed a genetic screen and isolated several suppressor mutants with proficient burrowing in a dys-1 mutant background. Further study of burrowing in C. elegans will enhance the study of diseases affecting neuromuscular integrity, and will provide insights into the natural behavior of this and other nematodes. äThe burrowing behavior of the nematode Caenorhabditis elegans: A new a(epmc).pdf DeepDyve Pubget Overpricing