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10.1074/jbc.M115.646737

http://scihub22266oqcxt.onion/10.1074/jbc.M115.646737
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suck abstract from ncbi


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pmid25866208      J+Biol+Chem 2015 ; 290 (22): 13692-709
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  • Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION* #MMPMID25866208
  • Cooper CDO; Newman JA; Aitkenhead H; Allerston CK; Gileadi O
  • J Biol Chem 2015[May]; 290 (22): 13692-709 PMID25866208show ga
  • Background: Transcription factors of the Ets family regulate development and cancer.Results: We show the details of DNA sequence recognition and identify structural changes that drastically affect DNA binding.Conclusion: The activity of Ets transcription factors is regulated by their oxidation state.Significance: Ets transcription factors may control the response of cells to oxygen levels.



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