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10.1002/art.39020 http://scihub22266oqcxt.onion/10.1002/art.39020 C4450082!4450082!25581113     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25581113&cmd=llinks): Failed to open stream: HTTP request failed! 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Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association with Disease Activity |pdf=|usr=}}{{25581113}} gab.com Text Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association with Disease Activity JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25581113 #FOAvip Objective: To assess circulating follicular helper-like CD4+ T (cTfh-like) cells in systemic lupus erythematosus (SLE) and determine their relationship to disease activity. Methods: We analyzed blood samples from SLE patients, and as controls, Behçet?s disease (BD) patients and healthy individuals. We used flow cytometry to enumerate cTfh-like cells using as markers the C-X-C chemokine receptor type 5 (CXCR5), inducible T-cell costimulator (ICOS), programmed cell death protein-1 (PCDC1, PD-1), and secretion of interleukin-21 (IL-21). We compared the frequency of cTfh-like cells with that of circulating plasmablasts (CD19+IgD?CD38+) and evaluated their possible association with disease activity. Results: cTfh-like T cells, identified as CXCR5hiICOShiPD-1hi, were expanded in the blood of SLE patients compared to BD and healthy controls. Such cells produced IL-21 with lower expression of CCR7, compared to circulating CXCR5hi central memory (Tcm) cells, enabling their distinction. PD-1, not ICOS or CXCR5, expression was significantly elevated in cTfh-like cells from SLE patients compared to controls. PD-1 expression among CXCR5hi cTfh-like cells correlated with disease activity, circulating plasmablasts, and anti-dsDNA antibody positivity, but not disease duration nor past organ injury; rather, it reflected current active disease. Conclusion: We found that cTfh-like cells are associated with disease activity in SLE, suggesting that their presence indicates abnormal homeostasis of T-B cell collaboration with a causal relationship central to disease pathogenesis. These findings also suggest that cTfh-like cells provide a surrogate for aberrant GC activity in SLE, and that their PD-1 expression offers a tool for following disease activity and response to therapies. Twit Text FOAVip Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association with Disease Activity ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=25581113 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25581113 #FOAvip English Wikipedia <ref>{{Cite pmid|25581113}}</ref> Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association with Disease Activity #MMPMID25581113 Choi JY; Ho JHe; Pasoto SG; Bunin V; Kim S; Carrasco S; Borba EF; Gonçalves CR; Costa PR; Kallas EG; Bonfa E; Craft J Arthritis Rheumatol 2015[Apr]; 67 (4): 988-99 PMID25581113show ga Objective: To assess circulating follicular helper-like CD4+ T (cTfh-like) cells in systemic lupus erythematosus (SLE) and determine their relationship to disease activity. Methods: We analyzed blood samples from SLE patients, and as controls, Behçet?s disease (BD) patients and healthy individuals. We used flow cytometry to enumerate cTfh-like cells using as markers the C-X-C chemokine receptor type 5 (CXCR5), inducible T-cell costimulator (ICOS), programmed cell death protein-1 (PCDC1, PD-1), and secretion of interleukin-21 (IL-21). We compared the frequency of cTfh-like cells with that of circulating plasmablasts (CD19+IgD?CD38+) and evaluated their possible association with disease activity. Results: cTfh-like T cells, identified as CXCR5hiICOShiPD-1hi, were expanded in the blood of SLE patients compared to BD and healthy controls. Such cells produced IL-21 with lower expression of CCR7, compared to circulating CXCR5hi central memory (Tcm) cells, enabling their distinction. PD-1, not ICOS or CXCR5, expression was significantly elevated in cTfh-like cells from SLE patients compared to controls. PD-1 expression among CXCR5hi cTfh-like cells correlated with disease activity, circulating plasmablasts, and anti-dsDNA antibody positivity, but not disease duration nor past organ injury; rather, it reflected current active disease. Conclusion: We found that cTfh-like cells are associated with disease activity in SLE, suggesting that their presence indicates abnormal homeostasis of T-B cell collaboration with a causal relationship central to disease pathogenesis. These findings also suggest that cTfh-like cells provide a surrogate for aberrant GC activity in SLE, and that their PD-1 expression offers a tool for following disease activity and response to therapies. äCirculating Follicular Helper-Like T Cells in Systemic Lupus Erythemat(epmc).pdf DeepDyve Pubget Overpricing