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10.1158/0008-5472.CAN-14-3485 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-3485 C4452414!4452414!25858145     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25858145&cmd=llinks): Failed to open stream: HTTP request failed! 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Silencing ?3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer |pdf=|usr=}}{{25858145}} gab.com Text Silencing 3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25858145 #FOAvip Metastatic breast cancer is the second leading cause of cancer-related deaths amongst women. Triple-negative breast cancer (TNBC) is a highly aggressive subcategory of breast cancer and currently lacks well-defined molecular targets for effective targeted therapies. Disease relapse, metastasis, and drug resistance render standard chemotherapy ineffective in the treatment of TNBC. Since previous studies coupled ?3 integrin to epithelial-mesenchymal transition (EMT) and metastasis, we exploited ?3 integrin as a therapeutic target to treat TNBC by delivering ?3 integrin siRNA via lipid ECO-based nanoparticles (ECO/si?3). Treatment of TNBC cells with ECO/si?3 was sufficient to effectively silence ?3 integrin expression, attenuate TGF-?-mediated EMT and invasion, restore TGF-?-mediated cytostasis, and inhibit 3-dimensional organoid growth. Modification of ECO/si?3 nanoparticles with an RGD peptide via a PEG spacer enhanced siRNA uptake by post-EMT cells. Intravenous injections of RGD-targeted ECO/si?3 nanoparticles in vivo alleviated primary tumor burden, and more importantly, significantly inhibited metastasis. Mice bearing orthotopic, TGF-?-pre-stimulated MDA-MB-231 tumors that were treated with RGD-targeted ECO/si?3 nanoparticles were free of metastases and relapse after primary tumor resection and 4 weeks after release from the treatment, in comparison to untreated mice. Collectively, these results highlight ECO/si?3 nanoparticles as a promising therapeutic regimen to combat TNBC. Twit Text FOAVip Silencing 3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25858145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25858145 #FOAvip English Wikipedia <ref>{{Cite pmid|25858145}}</ref> Silencing ?3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer #MMPMID25858145 Parvani JG; Gujrati MD; Mack MA; Schiemann WP; Lu ZR Cancer Res 2015[Jun]; 75 (11): 2316-25 PMID25858145show ga Metastatic breast cancer is the second leading cause of cancer-related deaths amongst women. Triple-negative breast cancer (TNBC) is a highly aggressive subcategory of breast cancer and currently lacks well-defined molecular targets for effective targeted therapies. Disease relapse, metastasis, and drug resistance render standard chemotherapy ineffective in the treatment of TNBC. Since previous studies coupled ?3 integrin to epithelial-mesenchymal transition (EMT) and metastasis, we exploited ?3 integrin as a therapeutic target to treat TNBC by delivering ?3 integrin siRNA via lipid ECO-based nanoparticles (ECO/si?3). Treatment of TNBC cells with ECO/si?3 was sufficient to effectively silence ?3 integrin expression, attenuate TGF-?-mediated EMT and invasion, restore TGF-?-mediated cytostasis, and inhibit 3-dimensional organoid growth. Modification of ECO/si?3 nanoparticles with an RGD peptide via a PEG spacer enhanced siRNA uptake by post-EMT cells. Intravenous injections of RGD-targeted ECO/si?3 nanoparticles in vivo alleviated primary tumor burden, and more importantly, significantly inhibited metastasis. Mice bearing orthotopic, TGF-?-pre-stimulated MDA-MB-231 tumors that were treated with RGD-targeted ECO/si?3 nanoparticles were free of metastases and relapse after primary tumor resection and 4 weeks after release from the treatment, in comparison to untreated mice. Collectively, these results highlight ECO/si?3 nanoparticles as a promising therapeutic regimen to combat TNBC. äSilencing ?3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT(epmc).pdf DeepDyve Pubget Overpricing