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10.1242/jcs.116426 http://scihub22266oqcxt.onion/10.1242/jcs.116426 C4481637!4481637!23264740     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23264740&cmd=llinks): Failed to open stream: HTTP request failed! 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PDGFR? signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2?ERK1/2?p90RSK and AKT signaling pathways |pdf=|usr=}}{{23264740}} gab.com Text PDGFR signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2 ERK1/2 p90RSK and AKT signaling pathways JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=23264740 #FOAvip In fibroblasts, platelet-derived growth factor receptor alpha (PDGFR?) is upregulated during growth arrest and compartmentalized to the primary cilium. PDGF-AA mediated activation of the dimerized ciliary receptor produces a phosphorylation cascade through the PI3K?AKT and MEK1/2?ERK1/2 pathways leading to the activation of the Na+/H+ exchanger, NHE1, cytoplasmic alkalinization and actin nucleation at the lamellipodium that supports directional cell migration. We here show that AKT and MEK1/2?ERK1/2?p90RSK inhibition reduced PDGF-AA-induced cell migration by distinct mechanisms: AKT inhibition reduced NHE1 activity by blocking the translocation of NHE1 to the cell membrane. MEK1/2 inhibition did not affect NHE1 activity but influenced NHE1 localization, causing NHE1 to localize discontinuously in patches along the plasma membrane, rather than preferentially at the lamellipodium. We also provide direct evidence of NHE1 translocation through the cytoplasm to the leading edge. In conclusion, signals initiated at the primary cilium through the PDGFR?? cascade reorganize the cytoskeleton to regulate cell migration differentially through the AKT and the MEK1/2?ERK1/2?p90RSK pathways. The AKT pathway is necessary for initiation of NHE1 translocation, presumably in vesicles, to the leading edge and for its activation. In contrast, the MEK1/2?ERK1/2?p90RSK pathway controls the spatial organization of NHE1 translocation and incorporation, and therefore specifies the direction of the leading edge formation. Twit Text FOAVip PDGFR signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2 ERK1/2 p90RSK and AKT signaling pathways ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=23264740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23264740 #FOAvip English Wikipedia <ref>{{Cite pmid|23264740}}</ref> PDGFR? signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2?ERK1/2?p90RSK and AKT signaling pathways #MMPMID23264740 Clement DL; Mally S; Stock C; Lethan M; Satir P; Schwab A; Pedersen SF; Christensen ST J Cell Sci 2013[Feb]; 126 (4): 953-65 PMID23264740show ga In fibroblasts, platelet-derived growth factor receptor alpha (PDGFR?) is upregulated during growth arrest and compartmentalized to the primary cilium. PDGF-AA mediated activation of the dimerized ciliary receptor produces a phosphorylation cascade through the PI3K?AKT and MEK1/2?ERK1/2 pathways leading to the activation of the Na+/H+ exchanger, NHE1, cytoplasmic alkalinization and actin nucleation at the lamellipodium that supports directional cell migration. We here show that AKT and MEK1/2?ERK1/2?p90RSK inhibition reduced PDGF-AA-induced cell migration by distinct mechanisms: AKT inhibition reduced NHE1 activity by blocking the translocation of NHE1 to the cell membrane. MEK1/2 inhibition did not affect NHE1 activity but influenced NHE1 localization, causing NHE1 to localize discontinuously in patches along the plasma membrane, rather than preferentially at the lamellipodium. We also provide direct evidence of NHE1 translocation through the cytoplasm to the leading edge. In conclusion, signals initiated at the primary cilium through the PDGFR?? cascade reorganize the cytoskeleton to regulate cell migration differentially through the AKT and the MEK1/2?ERK1/2?p90RSK pathways. The AKT pathway is necessary for initiation of NHE1 translocation, presumably in vesicles, to the leading edge and for its activation. In contrast, the MEK1/2?ERK1/2?p90RSK pathway controls the spatial organization of NHE1 translocation and incorporation, and therefore specifies the direction of the leading edge formation. äPDGFR? signaling in the primary cilium regulates NHE1-dependent fibrob(epmc).pdf DeepDyve Pubget Overpricing