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10.1136/archdischild-2014-307410 http://scihub22266oqcxt.onion/10.1136/archdischild-2014-307410 C4484494!4484494!25922190     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25922190&cmd=llinks): Failed to open stream: HTTP request failed! 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A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5?years |pdf=|usr=}}{{25922190}} gab.com Text A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years JO: Arch Dis Child Fetal Neonatal Ed http://www.kidney.de/pget.php?&tw=1&pmid=25922190 #FOAvip Objective: We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). GM-CSF was associated with improved neonatal neutrophil counts, but no change in other neonatal or 2-year outcomes. As subtle benefits in outcome may not be ascertainable until school age we performed an outcome study at 5?years. Patients and methods: 280 babies born at 31?weeks of gestation or less and SGA were entered into the trial. Outcomes were assessed at 5?years to determine neurodevelopmental and general health status and educational attainment. Results: We found no significant differences in cognitive, general health or educational outcomes between 83 of 106 (78%) surviving children in the GM-CSF arm compared with 81 of 110 (74%) in the control arm. Mean mental processing composite (equivalent to IQ) at 5?years were 94 (SD 16) compared with 95 (SD 15), respectively (difference in means ?1 (95%CI ?6 to 4), and similar proportions were in receipt of special educational needs support (41% vs 35%; risk ratio 1.2 (95% CI 0.8 to 1.9)). Performance on Kaufmann-ABC subscales and components of NEPSY were similar. The suggestion of worse respiratory outcomes in the GM-CSF group at 2?years was replicated at 5?years. Conclusions: The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse neurodevelopmental, general health or educational outcomes at 5?years. Trial registration number: ISRCTN42553489. Twit Text FOAVip A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years ????Arch Dis Child Fetal Neonatal Ed http://www.kidney.de/pget.php?&tw=1&pmid=25922190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25922190 #FOAvip English Wikipedia <ref>{{Cite pmid|25922190}}</ref> A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5?years #MMPMID25922190 Marlow N; Morris T; Brocklehurst P; Carr R; Cowan F; Patel N; Petrou S; Redshaw M; Modi N; Doré CJ Arch Dis Child Fetal Neonatal Ed 2015[Jul]; 100 (4): F320-6 PMID25922190show ga Objective: We performed a randomised trial in very preterm, small for gestational age (SGA) babies to determine if prophylaxis with granulocyte macrophage colony stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). GM-CSF was associated with improved neonatal neutrophil counts, but no change in other neonatal or 2-year outcomes. As subtle benefits in outcome may not be ascertainable until school age we performed an outcome study at 5?years. Patients and methods: 280 babies born at 31?weeks of gestation or less and SGA were entered into the trial. Outcomes were assessed at 5?years to determine neurodevelopmental and general health status and educational attainment. Results: We found no significant differences in cognitive, general health or educational outcomes between 83 of 106 (78%) surviving children in the GM-CSF arm compared with 81 of 110 (74%) in the control arm. Mean mental processing composite (equivalent to IQ) at 5?years were 94 (SD 16) compared with 95 (SD 15), respectively (difference in means ?1 (95%CI ?6 to 4), and similar proportions were in receipt of special educational needs support (41% vs 35%; risk ratio 1.2 (95% CI 0.8 to 1.9)). Performance on Kaufmann-ABC subscales and components of NEPSY were similar. The suggestion of worse respiratory outcomes in the GM-CSF group at 2?years was replicated at 5?years. Conclusions: The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse neurodevelopmental, general health or educational outcomes at 5?years. Trial registration number: ISRCTN42553489. äA randomised trial of granulocyte-macrophage colony-stimulating factor(epmc).pdf DeepDyve Pubget Overpricing