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10.1186/s40064-015-1106-4 http://scihub22266oqcxt.onion/10.1186/s40064-015-1106-4 C4489968!4489968!26155451     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26155451&cmd=llinks): Failed to open stream: HTTP request failed! 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Low-molecular-weight chitosan scavenges methylglyoxal and N?-(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy |pdf=|usr=}}{{26155451}} gab.com Text Low-molecular-weight chitosan scavenges methylglyoxal and N -(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy JO: Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26155451 #FOAvip Methylglyoxal (MG) can cause protein glycation, resulting in cell damage and dysfunction. Accumulation of MG and its downstream metabolite N?-(carboxyethyl)lysine (CEL) has been identified in several variations of nephropathy, including diabetic, hypertensive, and gentamicin-induced nephropathies. In this study, we investigated the effects of low-molecular-weight chitosan (lmw-chitosan) on MG-induced carbonyl stress in aristolochic acid-induced nephropathy. We used a buffer to investigate whether MG could be scavenged by lmw-chitosan in vitro. In addition, we also used a mouse model of aristolochic acid-induced nephropathy, which exhibits 12-fold greater accumulation of MG in the kidneys than that found in control animals, to examine whether lmw-chitosan could decrease MG levels in vivo. Examination of the binding of lmw-chitosan with MG in vitro demonstrated that the concentration of lmw-chitosan necessary to achieve 50% inhibition was 4.60 µg mL?1. Treatment with lmw-chitosan (500 mg kg?1 day?1 orally) for 14 days significantly decreased renal MG accumulation from 212.86 ± 24.34 to 86.15 ± 33.79 µg g?1 protein (p < 0.05) and CEL levels from 4.60 ± 0.27 to 2.84 ± 0.28 µmol µg?1 protein (p < 0.05) in the aristolochic acid-induced nephropathy model. These data suggest that lmw-chitosan might represent a novel treatment modality for MG-related diseases such as nephropathy.Electronic supplementary material: The online version of this article (doi:10.1186/s40064-015-1106-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Low-molecular-weight chitosan scavenges methylglyoxal and N -(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy ????Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26155451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26155451 #FOAvip English Wikipedia <ref>{{Cite pmid|26155451}}</ref> Low-molecular-weight chitosan scavenges methylglyoxal and N?-(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy #MMPMID26155451 Chou CK; Chen SM; Li YC; Huang TC; Lee JA Springerplus 2015[]; 4 (ä): ä PMID26155451show ga Methylglyoxal (MG) can cause protein glycation, resulting in cell damage and dysfunction. Accumulation of MG and its downstream metabolite N?-(carboxyethyl)lysine (CEL) has been identified in several variations of nephropathy, including diabetic, hypertensive, and gentamicin-induced nephropathies. In this study, we investigated the effects of low-molecular-weight chitosan (lmw-chitosan) on MG-induced carbonyl stress in aristolochic acid-induced nephropathy. We used a buffer to investigate whether MG could be scavenged by lmw-chitosan in vitro. In addition, we also used a mouse model of aristolochic acid-induced nephropathy, which exhibits 12-fold greater accumulation of MG in the kidneys than that found in control animals, to examine whether lmw-chitosan could decrease MG levels in vivo. Examination of the binding of lmw-chitosan with MG in vitro demonstrated that the concentration of lmw-chitosan necessary to achieve 50% inhibition was 4.60 µg mL?1. Treatment with lmw-chitosan (500 mg kg?1 day?1 orally) for 14 days significantly decreased renal MG accumulation from 212.86 ± 24.34 to 86.15 ± 33.79 µg g?1 protein (p < 0.05) and CEL levels from 4.60 ± 0.27 to 2.84 ± 0.28 µmol µg?1 protein (p < 0.05) in the aristolochic acid-induced nephropathy model. These data suggest that lmw-chitosan might represent a novel treatment modality for MG-related diseases such as nephropathy.Electronic supplementary material: The online version of this article (doi:10.1186/s40064-015-1106-4) contains supplementary material, which is available to authorized users. äLow-molecular-weight chitosan scavenges methylglyoxal and N?-(carboxye(epmc).pdf DeepDyve Pubget Overpricing