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http://scihub22266oqcxt.onion/ C4496368!4496368!25871389     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25871389&cmd=llinks): Failed to open stream: HTTP request failed! 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Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion |pdf=|usr=}}{{25871389}} gab.com Text Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25871389 #FOAvip The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion. Twit Text FOAVip Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25871389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25871389 #FOAvip English Wikipedia <ref>{{Cite pmid|25871389}}</ref> Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion #MMPMID25871389 Roselli S; Pundavela J; Demont Y; Faulkner S; Keene S; Attia J; Jiang CC; Zhang XD; Walker MM; Hondermarck H Oncotarget 2015[Apr]; 6 (12): 10473-86 PMID25871389show ga The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion. äSortilin is associated with breast cancer aggressiveness and contribut(epmc).pdf DeepDyve Pubget Overpricing