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10.1074/jbc.M114.633065

http://scihub22266oqcxt.onion/10.1074/jbc.M114.633065
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C4505538!4505538!25911105
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suck abstract from ncbi


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pmid25911105      J+Biol+Chem 2015 ; 290 (23): 14729-39
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  • Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon* #MMPMID25911105
  • Zhou Q; Lavorgna A; Bowman M; Hiscott J; Harhaj EW
  • J Biol Chem 2015[Jun]; 290 (23): 14729-39 PMID25911105show ga
  • Background: IRF7 is known as the master regulator of type I IFN production, yet little is known about its negative regulation.Results: AIP interacts with IRF7 and inhibits IRF7 nuclear localization.Conclusion: AIP suppresses virus-induced type I IFN production by targeting IRF7 for inactivation.Significance: Understanding IRF7 regulation is important to elucidate the host innate immune response to virus infection.
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