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10.3904/kjim.1994.9.1.9 http://scihub22266oqcxt.onion/10.3904/kjim.1994.9.1.9 C4532052!4532052!8038149     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\8038149.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Korean+J+Intern+Med 1994 ; 9 (1): 9-13 Nephropedia Template TP {{tp|p=8038149|t=1994. Effect of Angiotensin Converting Enzyme Inhibitor on Collagen Production by Cultured Mesangial Cells |pdf=|usr=}}{{8038149}} gab.com Text Effect of Angiotensin Converting Enzyme Inhibitor on Collagen Production by Cultured Mesangial Cells JO: Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=8038149 #FOAvip Cultured mesangial cells (MC) express renin mRNA and generate angiotensin I, supporting the action of local renin-angiotensin system. Also angiotensin II may act like a growth factor and was reported to increase collagen production (CP) in cultured MC. Angiotensin converting enzyme inhibitor is suggested to attenuate development and advancement of glomerulosclerosis, mainly with its hemodynamic effects. Therefore, we investigated the direct effects of enalapril (E) on CP by cultured MC. Rat MC were cultured in DMEM media alone, or containing high glucose (HG: 25 mM) or soluble immune complex (IC) prepared with bovine gamma globulin (BGG) and anti-BGG, with or without E (0.2 ug/ml). CP was determined after 24 h by [3H] proline incorporation method. E significantly reduced CP by 43% in medium as compared with control (C)(C: 37,210±4,200 vs C+E: 21,350 ± 5,080 cpm/well, p<0.01). CP in medium increased in the presence of HG (123% of C) or IC (147% of C), which was, however, prevented with E (HG + E: 105% of C, IC+E: 116% of C). There were no differences of CP in cell layer between C (3,490±220 cpm/well) and C+E (3,340±190 cpm/well), and also no changes after, addition of E in HG or IC groups. In conclusion, E directly attenuates CP by MC, even in the presence of HG or IC, independently of its hemodynamic effects. Twit Text FOAVip Effect of Angiotensin Converting Enzyme Inhibitor on Collagen Production by Cultured Mesangial Cells ????Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=8038149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=8038149 #FOAvip English Wikipedia <ref>{{Cite pmid|8038149}}</ref> Effect of Angiotensin Converting Enzyme Inhibitor on Collagen Production by Cultured Mesangial Cells #MMPMID8038149 Ihm CG; Park JK; Ahn JH; Lee TW; Kim MJ Korean J Intern Med 1994[Jan]; 9 (1): 9-13 PMID8038149show ga Cultured mesangial cells (MC) express renin mRNA and generate angiotensin I, supporting the action of local renin-angiotensin system. Also angiotensin II may act like a growth factor and was reported to increase collagen production (CP) in cultured MC. Angiotensin converting enzyme inhibitor is suggested to attenuate development and advancement of glomerulosclerosis, mainly with its hemodynamic effects. Therefore, we investigated the direct effects of enalapril (E) on CP by cultured MC. Rat MC were cultured in DMEM media alone, or containing high glucose (HG: 25 mM) or soluble immune complex (IC) prepared with bovine gamma globulin (BGG) and anti-BGG, with or without E (0.2 ug/ml). CP was determined after 24 h by [3H] proline incorporation method. E significantly reduced CP by 43% in medium as compared with control (C)(C: 37,210±4,200 vs C+E: 21,350 ± 5,080 cpm/well, p<0.01). CP in medium increased in the presence of HG (123% of C) or IC (147% of C), which was, however, prevented with E (HG + E: 105% of C, IC+E: 116% of C). There were no differences of CP in cell layer between C (3,490±220 cpm/well) and C+E (3,340±190 cpm/well), and also no changes after, addition of E in HG or IC groups. In conclusion, E directly attenuates CP by MC, even in the presence of HG or IC, independently of its hemodynamic effects. äEffect of Angiotensin Converting Enzyme Inhibitor on Collagen Producti(epmc).pdf DeepDyve Pubget Overpricing