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10.3904/kjim.1987.2.1.8 http://scihub22266oqcxt.onion/10.3904/kjim.1987.2.1.8 C4534923!4534923!3154820     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\3154820.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Korean+J+Intern+Med 1987 ; 2 (1): 8-17 Nephropedia Template TP {{tp|p=3154820|t=1987. Morphological Change in Pancreatic Islets, Insulin Binding and Intracellular Glucose Metabolism in Adipocytes of Streptozotocin-induced Diabetic Rats* |pdf=|usr=}}{{3154820}} gab.com Text Morphological Change in Pancreatic Islets, Insulin Binding and Intracellular Glucose Metabolism in Adipocytes of Streptozotocin-induced Diabetic Rats* JO: Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=3154820 #FOAvip To examine the diabetogenic mechanism of streptozotocin, a histological study was performed on the pancreatic islets of male Wistar rats 7 days after an intravenous injection of streptozotocin (75 mg/kg). Furthermore, for the investigation into mechanism of insulin resistance in the insulin-dependent diabetic rats, insulin binding, glucose transport, and lipogenesis were studied in the isolated adipocytes of streptozotocin-induced diabetic rats. 1) The rate of weight gain in the control rats and the diabetic rats were 2.2 ± 1.8 g/day and ?2.4 ± 2.1 g/day, respectively (p<0.05). The serum insulin levels in the control rats and the diabetic rats were 23.1 ± 10.8 ?U/ml and 16.9 ± 10.6 ?U/ml respectively (p<0.05). The plasma glucagon levels in the control rats and the diabetic rats were 165.7 ± 124.9 pg/ml. and 151.2 ± 78.2 pg/ml, respectively (p>0.1).2) Microscopic examination of the pancreatic islets of the diabetic rats revealed a severe degranulation and disintegration of B cells. Electron microscopic examination showed a disruption of the intracytoplasmic organelles of B cells with complete degranulation. But the morphology of A cells was normal.3) Maximal specific insulin binding to receptors in the adipocytes of the diabetic rats (2.10 ± 0.30%) showed an increase compared with that of the control rats (1.12 ± 0.21 %) (p<0.05).4) Insulin receptor concentration in the adipocytes of the diabetic rats (2.33 ± 0.43 ng/0.5 × 105 cells) also showed an increase compared with that of control rats (1.03 ± 0.15 ng/0.5 × 105 cells) (p<0.05).5) The average affinities in the adipocytes of the diabetic rats slightly decreased in the low receptor occupancy state compared with that of the control rats.6) Basal and insulin-stimulated glucose transports in adipocytes of the diabetic rats decreased compared with that of the control rats. The maximal glucose transport in the adipocytes of the diabetic rats was 31.7% of the control value (p<0.005).7) Basal and insulin-stimulated lipogenesis in adipocytes of the diabetic rats decreased compared with that of the control rats. The maximal lipogenesis in the adipocytes of the diabetic rats was 38.4% of the control value (p<0.005).It can be concluded that streptozotocin produces a diabetogenic mechanism in Wistar rats by directly injuring the pancreatic B cells and inducing hypoinsulinemia. The insulin resistance in the streptozotocin-induced diabetic rats results from the defects in the intracellular glucose metabolism such as glucose transport and lipogenesis. Twit Text FOAVip Morphological Change in Pancreatic Islets, Insulin Binding and Intracellular Glucose Metabolism in Adipocytes of Streptozotocin-induced Diabetic Rats* ????Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=3154820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=3154820 #FOAvip English Wikipedia <ref>{{Cite pmid|3154820}}</ref> Morphological Change in Pancreatic Islets, Insulin Binding and Intracellular Glucose Metabolism in Adipocytes of Streptozotocin-induced Diabetic Rats* #MMPMID3154820 Cha BY; Son HY; Min BS; Kim HJ Korean J Intern Med 1987[Jan]; 2 (1): 8-17 PMID3154820show ga To examine the diabetogenic mechanism of streptozotocin, a histological study was performed on the pancreatic islets of male Wistar rats 7 days after an intravenous injection of streptozotocin (75 mg/kg). Furthermore, for the investigation into mechanism of insulin resistance in the insulin-dependent diabetic rats, insulin binding, glucose transport, and lipogenesis were studied in the isolated adipocytes of streptozotocin-induced diabetic rats. 1) The rate of weight gain in the control rats and the diabetic rats were 2.2 ± 1.8 g/day and ?2.4 ± 2.1 g/day, respectively (p<0.05). The serum insulin levels in the control rats and the diabetic rats were 23.1 ± 10.8 ?U/ml and 16.9 ± 10.6 ?U/ml respectively (p<0.05). The plasma glucagon levels in the control rats and the diabetic rats were 165.7 ± 124.9 pg/ml. and 151.2 ± 78.2 pg/ml, respectively (p>0.1).2) Microscopic examination of the pancreatic islets of the diabetic rats revealed a severe degranulation and disintegration of B cells. Electron microscopic examination showed a disruption of the intracytoplasmic organelles of B cells with complete degranulation. But the morphology of A cells was normal.3) Maximal specific insulin binding to receptors in the adipocytes of the diabetic rats (2.10 ± 0.30%) showed an increase compared with that of the control rats (1.12 ± 0.21 %) (p<0.05).4) Insulin receptor concentration in the adipocytes of the diabetic rats (2.33 ± 0.43 ng/0.5 × 105 cells) also showed an increase compared with that of control rats (1.03 ± 0.15 ng/0.5 × 105 cells) (p<0.05).5) The average affinities in the adipocytes of the diabetic rats slightly decreased in the low receptor occupancy state compared with that of the control rats.6) Basal and insulin-stimulated glucose transports in adipocytes of the diabetic rats decreased compared with that of the control rats. The maximal glucose transport in the adipocytes of the diabetic rats was 31.7% of the control value (p<0.005).7) Basal and insulin-stimulated lipogenesis in adipocytes of the diabetic rats decreased compared with that of the control rats. The maximal lipogenesis in the adipocytes of the diabetic rats was 38.4% of the control value (p<0.005).It can be concluded that streptozotocin produces a diabetogenic mechanism in Wistar rats by directly injuring the pancreatic B cells and inducing hypoinsulinemia. The insulin resistance in the streptozotocin-induced diabetic rats results from the defects in the intracellular glucose metabolism such as glucose transport and lipogenesis. äMorphological Change in Pancreatic Islets, Insulin Binding and Intrace(epmc).pdf DeepDyve Pubget Overpricing