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10.1155/2015/709846

http://scihub22266oqcxt.onion/10.1155/2015/709846
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suck abstract from ncbi


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pmid26347020      Biomed+Res+Int 2015 ; 2015 (ä): ä
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  • Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease #MMPMID26347020
  • Flávia Nardy A; Santos L; Freire-de-Lima CG; Morrot A
  • Biomed Res Int 2015[]; 2015 (ä): ä PMID26347020show ga
  • The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis that ultimately promotes the premature exit of immature CD4?CD8? T cells expressing TCR and proinflamatory cytokines to peripheral lymphoid organs, where they may interfere with adaptive immune responses. In what follows, we review recent findings revealing escape of these immature T cells exhibiting an activation profile to peripheral compartments of the immune system in both experimental murine and human models of Chagas disease.
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