Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1155/2015/843743 http://scihub22266oqcxt.onion/10.1155/2015/843743 C4561300!4561300!26380299     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26380299.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26380299|t=2015. Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGF?1 Transgenic Mice |pdf=|usr=}}{{26380299}} gab.com Text Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGF 1 Transgenic Mice JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26380299 #FOAvip Transforming growth factor beta 1 (TGF?1) is a key player in skeletal muscle degenerative and regenerative processes. We previously showed that conditionally overexpressing TGF?1 in skeletal muscles caused myofiber atrophy and endomysial fibrosis in mice. However, the disease severity varied significantly among individual mice. While 40% of mice developed severe muscle pathology and lost body weight within 2 weeks of TGF?1 transgene induction in muscles, the rest showed milder or no phenotype. This study aims at determining whether signal transducer and activator of transcription 3 (STAT3) plays a role in the phenotypic difference and whether it can be activated by TGF?1 directly in muscle cells. Our results show that while total STAT3 was not differentially expressed between the two groups of mice, there was significantly higher pSTAT3 (Tyr705) in the muscles of the mice with severe phenotype. Immunohistochemistry showed that pSTAT3 (Tyr705) was localized in approximately 50% of the nuclei of the muscles. We further showed that TGF?1 induced Tyr705 phosphorylation of STAT3 in C2C12 cells within 30 minutes of treatment while total STAT3 was not affected. Our findings suggest that TGF?1 alone can induce Tyr705 phosphorylation of STAT3 in skeletal muscle cells and contribute to disease severity in transgenic TGF?1 mice. Twit Text FOAVip Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGF 1 Transgenic Mice ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26380299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26380299 #FOAvip English Wikipedia <ref>{{Cite pmid|26380299}}</ref> Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGF?1 Transgenic Mice #MMPMID26380299 Guadagnin E; Narola J; Bönnemann CG; Chen YW Biomed Res Int 2015[]; 2015 (ä): ä PMID26380299show ga Transforming growth factor beta 1 (TGF?1) is a key player in skeletal muscle degenerative and regenerative processes. We previously showed that conditionally overexpressing TGF?1 in skeletal muscles caused myofiber atrophy and endomysial fibrosis in mice. However, the disease severity varied significantly among individual mice. While 40% of mice developed severe muscle pathology and lost body weight within 2 weeks of TGF?1 transgene induction in muscles, the rest showed milder or no phenotype. This study aims at determining whether signal transducer and activator of transcription 3 (STAT3) plays a role in the phenotypic difference and whether it can be activated by TGF?1 directly in muscle cells. Our results show that while total STAT3 was not differentially expressed between the two groups of mice, there was significantly higher pSTAT3 (Tyr705) in the muscles of the mice with severe phenotype. Immunohistochemistry showed that pSTAT3 (Tyr705) was localized in approximately 50% of the nuclei of the muscles. We further showed that TGF?1 induced Tyr705 phosphorylation of STAT3 in C2C12 cells within 30 minutes of treatment while total STAT3 was not affected. Our findings suggest that TGF?1 alone can induce Tyr705 phosphorylation of STAT3 in skeletal muscle cells and contribute to disease severity in transgenic TGF?1 mice. äTyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Sev(epmc).pdf DeepDyve Pubget Overpricing