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10.3892/ijmm.2015.2299 http://scihub22266oqcxt.onion/10.3892/ijmm.2015.2299 C4564088!4564088!26239419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26239419&cmd=llinks): Failed to open stream: HTTP request failed! 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Shikonin reduces TGF-?1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts |pdf=|usr=}}{{26239419}} gab.com Text Shikonin reduces TGF- 1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26239419 #FOAvip Hypertrophic scarring/hypertrophic scars (HS) is a highly prevalent condition following burns and trauma wounds. Numerous studies have demonstrated that transforming growth factor-?1 (TGF-?1) plays an essential role in the wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation. The increased expression of TGF-?1 is believed to result in the formation of HS. Shikonin (SHI), an active component extracted from the Chinese herb, Radix Arnebiae, has previously been found to downregulate the expression of TGF-?1 in keratinocyte/fibroblast co-culture conditioned medium. In view of this, in this study, we aimed to further investigate the effects of SHI on TGF-?1-stimulated hypertrophic scar-derived human skin fibroblasts (HSFs) and examined the underlying mechanisms. Cell viability and proliferation were measured using alamarBlue and CyQUANT assays. The total amount of collagen and cell contraction were examined using Sirius red staining and the cell contraction assay kit. Gene expression and signalling pathway activation were detected using reverse transcription-quantitative polymerase chain reaction and western blot analysis. Our results revealed that SHI reduced TGF-?1-induced collagen production through the ERK/Smad signalling pathway and attenuated TGF-?1-induced cell contraction by downregulating ?-smooth muscle actin (?SMA) expression in the HSFs. The data from this study provide evidence supporting the potential use of SHI as a novel treatment for HS. Twit Text FOAVip Shikonin reduces TGF- 1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26239419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26239419 #FOAvip English Wikipedia <ref>{{Cite pmid|26239419}}</ref> Shikonin reduces TGF-?1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts #MMPMID26239419 FAN C; DONG Y; XIE Y; SU Y; ZHANG X; LEAVESLEY D; UPTON Z Int J Mol Med 2015[Oct]; 36 (4): 985-91 PMID26239419show ga Hypertrophic scarring/hypertrophic scars (HS) is a highly prevalent condition following burns and trauma wounds. Numerous studies have demonstrated that transforming growth factor-?1 (TGF-?1) plays an essential role in the wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation. The increased expression of TGF-?1 is believed to result in the formation of HS. Shikonin (SHI), an active component extracted from the Chinese herb, Radix Arnebiae, has previously been found to downregulate the expression of TGF-?1 in keratinocyte/fibroblast co-culture conditioned medium. In view of this, in this study, we aimed to further investigate the effects of SHI on TGF-?1-stimulated hypertrophic scar-derived human skin fibroblasts (HSFs) and examined the underlying mechanisms. Cell viability and proliferation were measured using alamarBlue and CyQUANT assays. The total amount of collagen and cell contraction were examined using Sirius red staining and the cell contraction assay kit. Gene expression and signalling pathway activation were detected using reverse transcription-quantitative polymerase chain reaction and western blot analysis. Our results revealed that SHI reduced TGF-?1-induced collagen production through the ERK/Smad signalling pathway and attenuated TGF-?1-induced cell contraction by downregulating ?-smooth muscle actin (?SMA) expression in the HSFs. The data from this study provide evidence supporting the potential use of SHI as a novel treatment for HS. äShikonin reduces TGF-?1-induced collagen production and contraction in(epmc).pdf DeepDyve Pubget Overpricing