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10.1016/j.chom.2015.07.016 http://scihub22266oqcxt.onion/10.1016/j.chom.2015.07.016 C4567510!4567510!26320999     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26320999&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26320999.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Host+Microbe 2015 ; 18 (3): 320-32 Nephropedia Template TP {{tp|p=26320999|t=2015. Canonical inflammasomes drive IFN-? to prime caspase-11 in defense against a cytosol-invasive bacterium |pdf=|usr=}}{{26320999}} gab.com Text Canonical inflammasomes drive IFN- to prime caspase-11 in defense against a cytosol-invasive bacterium JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26320999 #FOAvip The inflammatory caspases-1 and -11 are activated in response to different agonists and act independently to induce pyroptosis. In the context of IL-1?/IL-18 secretion however, in vitro studies indicate that caspase-11 acts upstream of NLRP3 and caspase-1. By contrast, studying infection in vivo by the cytosol-invasive bacterium Burkholderia thailandensis, we find that caspase-1 activity is required upstream of caspase-11 to control infection. Caspase-1 activated IL-18 induces IFN-? to prime caspase-11 and rapidly clear B. thailandensis infection. In the absence of IL-18, bacterial burdens persist, eventually triggering other signals that induce IFN-?. Whereas IFN-? was essential, endogenous type I interferons were insufficient to prime caspase-11. Although mice transgenic for caspase-4, the human orthologue of caspase-11, cleared B. thailandensis in vivo, they did not strictly require IFN-? priming. Thus, caspase-1 provides priming signals upstream of caspase-11 but not caspase-4 during murine defense against a cytosol-invasive bacterium. Twit Text FOAVip Canonical inflammasomes drive IFN- to prime caspase-11 in defense against a cytosol-invasive bacterium ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=26320999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26320999 #FOAvip English Wikipedia <ref>{{Cite pmid|26320999}}</ref> Canonical inflammasomes drive IFN-? to prime caspase-11 in defense against a cytosol-invasive bacterium #MMPMID26320999 Aachoui Y; Kajiwara Y; Leaf IA; Mao D; Ting JPY; Coers J; Aderem A; Buxbaum JD; Miao EA Cell Host Microbe 2015[Sep]; 18 (3): 320-32 PMID26320999show ga The inflammatory caspases-1 and -11 are activated in response to different agonists and act independently to induce pyroptosis. In the context of IL-1?/IL-18 secretion however, in vitro studies indicate that caspase-11 acts upstream of NLRP3 and caspase-1. By contrast, studying infection in vivo by the cytosol-invasive bacterium Burkholderia thailandensis, we find that caspase-1 activity is required upstream of caspase-11 to control infection. Caspase-1 activated IL-18 induces IFN-? to prime caspase-11 and rapidly clear B. thailandensis infection. In the absence of IL-18, bacterial burdens persist, eventually triggering other signals that induce IFN-?. Whereas IFN-? was essential, endogenous type I interferons were insufficient to prime caspase-11. Although mice transgenic for caspase-4, the human orthologue of caspase-11, cleared B. thailandensis in vivo, they did not strictly require IFN-? priming. Thus, caspase-1 provides priming signals upstream of caspase-11 but not caspase-4 during murine defense against a cytosol-invasive bacterium. äCanonical inflammasomes drive IFN-? to prime caspase-11 in defense aga(epmc).pdf DeepDyve Pubget Overpricing