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10.1007/s00401-015-1477-1 http://scihub22266oqcxt.onion/10.1007/s00401-015-1477-1 C4575389!4575389!26363791     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26363791.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Neuropathol 2015 ; 130 (4): 487-99 Nephropedia Template TP {{tp|p=26363791|t=2015. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer?s disease |pdf=|usr=}}{{26363791}} gab.com Text Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer s disease JO: Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=26363791 #FOAvip Amyloid-beta (A?) plays a pivotal role in the pathogenesis of Alzheimer?s disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived A? and its therapeutic potential for AD remains largely unknown. Here, we measured blood A? levels in different locations of the circulation in humans and mice, and used a parabiosis model to investigate the effect of peripheral A? catabolism on AD pathogenesis. We found that blood A? levels in the inferior/posterior vena cava were lower than that in the superior vena cava in both humans and mice. In addition, injected 125I labeled A?40 was located mostly in the liver, kidney, gastrointestinal tract, and skin but very little in the brain; suggesting that A? derived from the brain can be cleared in the periphery. Parabiosis before and after A? deposition in the brain significantly reduced brain A? burden without alterations in the expression of amyloid precursor protein, A? generating and degrading enzymes, A? transport receptors, and AD-type pathologies including hyperphosphorylated tau, neuroinflammation, as well as neuronal degeneration and loss in the brains of parabiotic AD mice. Our study revealed that the peripheral system is potent in clearing brain A? and preventing AD pathogenesis. The present work suggests that peripheral A? clearance is a valid therapeutic approach for AD, and implies that deficits in the A? clearance in the periphery might also contribute to AD pathogenesis.Electronic supplementary material: The online version of this article (doi:10.1007/s00401-015-1477-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer s disease ????Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=26363791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26363791 #FOAvip English Wikipedia <ref>{{Cite pmid|26363791}}</ref> Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer?s disease #MMPMID26363791 Xiang Y; Bu XL; Liu YH; Zhu C; Shen LL; Jiao SS; Zhu XY; Giunta B; Tan J; Song WH; Zhou HD; Zhou XF; Wang YJ Acta Neuropathol 2015[]; 130 (4): 487-99 PMID26363791show ga Amyloid-beta (A?) plays a pivotal role in the pathogenesis of Alzheimer?s disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived A? and its therapeutic potential for AD remains largely unknown. Here, we measured blood A? levels in different locations of the circulation in humans and mice, and used a parabiosis model to investigate the effect of peripheral A? catabolism on AD pathogenesis. We found that blood A? levels in the inferior/posterior vena cava were lower than that in the superior vena cava in both humans and mice. In addition, injected 125I labeled A?40 was located mostly in the liver, kidney, gastrointestinal tract, and skin but very little in the brain; suggesting that A? derived from the brain can be cleared in the periphery. Parabiosis before and after A? deposition in the brain significantly reduced brain A? burden without alterations in the expression of amyloid precursor protein, A? generating and degrading enzymes, A? transport receptors, and AD-type pathologies including hyperphosphorylated tau, neuroinflammation, as well as neuronal degeneration and loss in the brains of parabiotic AD mice. Our study revealed that the peripheral system is potent in clearing brain A? and preventing AD pathogenesis. The present work suggests that peripheral A? clearance is a valid therapeutic approach for AD, and implies that deficits in the A? clearance in the periphery might also contribute to AD pathogenesis.Electronic supplementary material: The online version of this article (doi:10.1007/s00401-015-1477-1) contains supplementary material, which is available to authorized users. äPhysiological amyloid-beta clearance in the periphery and its therapeu(epmc).pdf DeepDyve Pubget Overpricing