
| 10.1038/srep14207
http://scihub22266oqcxt.onion/10.1038/srep14207
 C4585804!4585804!26395309
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Entrainment of mouse peripheral circadian clocks to 24?h feeding/fasting cycles under 24?h light/dark conditions #MMPMID26395309Hamaguchi Y; Tahara Y; Kuroda H; Haraguchi A; Shibata SSci Rep 2015[]; 5 (�): � PMID26395309show ga
The circadian clock system in peripheral tissues can endogenously oscillate and is entrained by the light-dark and fasting-feeding cycles in mammals. Although the system?s range of entrainment to light-dark cycles with a non-24?h (<24?h) interval has been studied, the range of entrainment to fasting-feeding cycles with shorter periods (<24?h) has not been investigated in peripheral molecular clocks. In the present study, we measured this range by monitoring the mouse peripheral PER2::LUCIFERASE rhythm in vivo at different periods under each feeding cycle (Tau (T)?=?15?24?h) under normal light-dark conditions. Peripheral clocks could be entrained to the feeding cycle with T?=?22?24?h, but not to that with T?=?15?21?h. Under the feeding cycle with T?=?15?18?h, the peripheral clocks oscillated at near the 24-h period, suggesting that they were entrained to the light-dark cycle. Thus, for the first time, we demonstrated the range of entrainment to the non-24?h feeding cycle, and that the circadian range (T?=?22?24?h) of feeding stimulus is necessary for peripheral molecular clock entrainment under light-dark cycles.�
  
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