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10.1093/ije/dyu277 http://scihub22266oqcxt.onion/10.1093/ije/dyu277 C4588858!4588858!25617346     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25617346.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Epidemiol 2015 ; 44 (4): 1388-96 Nephropedia Template TP {{tp|p=25617346|t=2015. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 |pdf=|usr=}}{{25617346}} gab.com Text The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 JO: Int J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=25617346 #FOAvip Background: The DNA methylation-based ?epigenetic clock? correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.Methods: DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n?=?920), 73 (n?=?299) and 76 (n?=?273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves. Epigenetic age acceleration at age 70 was used as a predictor of longitudinal change in fitness. Epigenome-wide association studies (EWASs) were conducted on the four fitness measures.Results: Cross-sectional correlations were significant between greater age acceleration and poorer performance on the lung function, cognition and grip strength measures (r range: ?0.07 to ?0.05, P range: 9.7?x?10?3 to 0.024). All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years. There were no EWAS hits for the fitness traits.Conclusions: Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration). However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up. Twit Text FOAVip The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 ????Int J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=25617346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25617346 #FOAvip English Wikipedia <ref>{{Cite pmid|25617346}}</ref> The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 #MMPMID25617346 Marioni RE; Shah S; McRae AF; Ritchie SJ; Muniz-Terrera G; Harris SE; Gibson J; Redmond P; Cox SR; Pattie A; Corley J; Taylor A; Murphy L; Starr JM; Horvath S; Visscher PM; Wray NR; Deary IJ Int J Epidemiol 2015[Aug]; 44 (4): 1388-96 PMID25617346show ga Background: The DNA methylation-based ?epigenetic clock? correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.Methods: DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n?=?920), 73 (n?=?299) and 76 (n?=?273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves. Epigenetic age acceleration at age 70 was used as a predictor of longitudinal change in fitness. Epigenome-wide association studies (EWASs) were conducted on the four fitness measures.Results: Cross-sectional correlations were significant between greater age acceleration and poorer performance on the lung function, cognition and grip strength measures (r range: ?0.07 to ?0.05, P range: 9.7?x?10?3 to 0.024). All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years. There were no EWAS hits for the fitness traits.Conclusions: Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration). However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up. äThe epigenetic clock is correlated with physical and cognitive fitness(epmc).pdf DeepDyve Pubget Overpricing