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10.4161/cam.28988 http://scihub22266oqcxt.onion/10.4161/cam.28988 C4594580!4594580!25482639     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25482639.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Adh+Migr 2014 ; 8 (4): 389-95 Nephropedia Template TP {{tp|p=25482639|t=2014. Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells |pdf=|usr=}}{{25482639}} gab.com Text Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells JO: Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=25482639 #FOAvip Fibrillin-1 is a microfibrillar extracellular matrix protein that was described to be a ligand for ?8 integrin. ?8 integrin is a matrix receptor specifically expressed in mesangial and smooth muscle cells of the kidney. In previous studies we detected glomerular expression of fibrillin-1. Moreover, fibrillin-1 promoted adhesion, migration, and proliferation of mesangial cells. We hypothesized that fibrillin-1 and ?8 integrin might interact in the glomerulus, and thus, regulate mesangial cell properties. Our studies showed that fibrillin-1 and ?8 integrin colocalize in the glomerular mesangium. Induction of experimental glomerulonephritis led to an increase of both fibrillin-1 and ?8 integrin expression. In vitro studies revealed that mesangial cells deficient for ?8 integrin adhere weaker to fibrillin-1 and migrate more easily on fibrillin-1 than wild-type mesangial cells. Baseline proliferation on fibrillin-1 is higher in ?8 integrin-deficient mesangial cells, but the induction of proliferation is not different in ?8 integrin-deficient and wild-type mesangial cells. We conclude that fibrillin-1 and ?8 integrin interact, and thus, regulate mesangial cell adhesion and migration. The concomitant induction of both fibrillin-1 and ?8 integrin in a self-limited model of glomerular injury points to a protective role of the interaction of fibrillin-1 with ?8 integrin in the glomerulus resulting in reduced damage of the glomerular tuft as a consequence of firm adhesion of mesangial cells. Twit Text FOAVip Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells ????Cell Adh Migr http://www.kidney.de/pget.php?&tw=1&pmid=25482639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25482639 #FOAvip English Wikipedia <ref>{{Cite pmid|25482639}}</ref> Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells #MMPMID25482639 Marek I; Volkert G; Hilgers KF; Bieritz B; Rascher W; Reinhardt DP; Hartner A Cell Adh Migr 2014[Jul]; 8 (4): 389-95 PMID25482639show ga Fibrillin-1 is a microfibrillar extracellular matrix protein that was described to be a ligand for ?8 integrin. ?8 integrin is a matrix receptor specifically expressed in mesangial and smooth muscle cells of the kidney. In previous studies we detected glomerular expression of fibrillin-1. Moreover, fibrillin-1 promoted adhesion, migration, and proliferation of mesangial cells. We hypothesized that fibrillin-1 and ?8 integrin might interact in the glomerulus, and thus, regulate mesangial cell properties. Our studies showed that fibrillin-1 and ?8 integrin colocalize in the glomerular mesangium. Induction of experimental glomerulonephritis led to an increase of both fibrillin-1 and ?8 integrin expression. In vitro studies revealed that mesangial cells deficient for ?8 integrin adhere weaker to fibrillin-1 and migrate more easily on fibrillin-1 than wild-type mesangial cells. Baseline proliferation on fibrillin-1 is higher in ?8 integrin-deficient mesangial cells, but the induction of proliferation is not different in ?8 integrin-deficient and wild-type mesangial cells. We conclude that fibrillin-1 and ?8 integrin interact, and thus, regulate mesangial cell adhesion and migration. The concomitant induction of both fibrillin-1 and ?8 integrin in a self-limited model of glomerular injury points to a protective role of the interaction of fibrillin-1 with ?8 integrin in the glomerulus resulting in reduced damage of the glomerular tuft as a consequence of firm adhesion of mesangial cells. äFibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and(epmc).pdf DeepDyve Pubget Overpricing