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10.1371/journal.pone.0140249

http://scihub22266oqcxt.onion/10.1371/journal.pone.0140249
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suck abstract from ncbi


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pmid26448474      PLoS+One 2015 ; 10 (10): �
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  • Euphol from Euphorbia tirucalli Negatively Modulates TGF-? Responsiveness via TGF-? Receptor Segregation inside Membrane Rafts #MMPMID26448474
  • Chen CL; Chen YP; Lin MW; Huang YB; Chang FR; Duh TH; Wu DC; Wu WC; Kao YC; Yang PH
  • PLoS One 2015[]; 10 (10): � PMID26448474show ga
  • Transforming growth factor-? (TGF-?) responsiveness in cultured cells can be modulated by TGF-? partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts? structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-? signaling by inducing TGF-? receptor movement into lipid-raft microdomains and degrading TGF-? receptors.



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