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10.1097/MD.0000000000000480

http://scihub22266oqcxt.onion/10.1097/MD.0000000000000480
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C4602713!4602713!25654389
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suck abstract from ncbi


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pmid25654389      Medicine+(Baltimore) 2015 ; 94 (5): ä
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  • Successful Treatment of Fibrosing Cholestatic Hepatitis Following Kidney Transplantation With Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report #MMPMID25654389
  • Li DL; Fang J; Zheng Z; Wu W; Wu Z
  • Medicine (Baltimore) 2015[Feb]; 94 (5): ä PMID25654389show ga
  • Fibrosing cholestatic hepatitis (FCH) is an uncommon complication of renal transplantation and usually associated with hepatitis B and C viral infection. Without treatment, the prognosis is usually fatal within weeks of onset. There was rarely report with successful treatment intervention.This case report describes a uremic patient with HCV infection who developed a fatal form of FCH after kidney transplantation. This is the first reported successful case with allogeneic hematopoietic stem cell transplantation (AHSCT) without ablative conditioning.A dramatic virologic and clinical improvement was observed in this post-transplantation patient. But no adverse events related to AHSCT were observed. The patient returned to work full-time at 10 months of hospitalization and is still in good health by now. Serum HCV RNA gradually decreased from 2.5?×?106?Copies/mL at day 1 to 3.2?×?104?Copies/mL at day 98 and became negative (<400?Copies/mL) at day 126 of hospitalization and remains negative at the last available assessment.Our report suggests that allogeneic HSCT may have a therapeutic role in FCH.
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