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10.1093/nar/gkv814 http://scihub22266oqcxt.onion/10.1093/nar/gkv814 C4605304!4605304!26261209     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26261209&cmd=llinks): Failed to open stream: HTTP request failed! 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TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways |pdf=|usr=}}{{26261209}} gab.com Text TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26261209 #FOAvip In recent times, high-throughput screening analyses have broadly defined the RNA cellular targets of TDP-43, a nuclear factor involved in neurodegeneration. A common outcome of all these studies is that changing the expression levels of this protein can alter the expression of several hundred RNAs within cells. What still remains to be clarified is which changes represent direct cellular targets of TDP-43 or just secondary variations due to the general role played by this protein in RNA metabolism. Using an HTS-based splicing junction analysis we identified at least six bona fide splicing events that are consistent with being controlled by TDP-43. Validation of the data, both in neuronal and non-neuronal cell lines demonstrated that TDP-43 substantially alters the levels of isoform expression in four genes potentially important for neuropathology: MADD/IG20, STAG2, FNIP1 and BRD8. For MADD/IG20 and STAG2, these changes could also be confirmed at the protein level. These alterations were also observed in a cellular model that successfully mimics TDP-43 loss of function effects following its aggregation. Most importantly, our study demonstrates that cell cycle alterations induced by TDP-43 knockdown can be recovered by restoring the STAG2, an important component of the cohesin complex, normal splicing profile. Twit Text FOAVip TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=26261209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26261209 #FOAvip English Wikipedia <ref>{{Cite pmid|26261209}}</ref> TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways #MMPMID26261209 De�Conti L; Akinyi MV; Mendoza-Maldonado R; Romano M; Baralle M; Buratti E Nucleic Acids Res 2015[Oct]; 43 (18): 8990-9005 PMID26261209show ga In recent times, high-throughput screening analyses have broadly defined the RNA cellular targets of TDP-43, a nuclear factor involved in neurodegeneration. A common outcome of all these studies is that changing the expression levels of this protein can alter the expression of several hundred RNAs within cells. What still remains to be clarified is which changes represent direct cellular targets of TDP-43 or just secondary variations due to the general role played by this protein in RNA metabolism. Using an HTS-based splicing junction analysis we identified at least six bona fide splicing events that are consistent with being controlled by TDP-43. Validation of the data, both in neuronal and non-neuronal cell lines demonstrated that TDP-43 substantially alters the levels of isoform expression in four genes potentially important for neuropathology: MADD/IG20, STAG2, FNIP1 and BRD8. For MADD/IG20 and STAG2, these changes could also be confirmed at the protein level. These alterations were also observed in a cellular model that successfully mimics TDP-43 loss of function effects following its aggregation. Most importantly, our study demonstrates that cell cycle alterations induced by TDP-43 knockdown can be recovered by restoring the STAG2, an important component of the cohesin complex, normal splicing profile. �TDP-43 affects splicing profiles and isoform production of genes invol(epmc).pdf DeepDyve Pubget Overpricing