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10.1111/imm.12525

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C4610624!4610624!26301993
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suck abstract from ncbi


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pmid26301993      Immunology 2015 ; 146 (3): 349-58
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  • Chrono-immunology: progress and challenges in understanding links between the circadian and immune systems #MMPMID26301993
  • Geiger SS; Fagundes CT; Siegel RM
  • Immunology 2015[Nov]; 146 (3): 349-58 PMID26301993show ga
  • Development of inflammatory diseases, such as metabolic syndrome and cancer, is prevalent in individuals that encounter continuous disruption of their internal clock. Further, daily oscillations in susceptibility to infection as well as a multitude of other immunological processes have been described. Much progress has been made and various mechanisms have been proposed to explain circadian variations in immunity; yet much is still unknown. Understanding the crosstalk between the circadian and the immune systems will allow us to manipulate clock outputs to prevent and treat inflammatory diseases in individuals at risk. This review briefly summarizes current knowledge about circadian rhythms and their role in the immune system and highlights progress and challenges in chrono-immunological research.



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